{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T21:14:22Z","timestamp":1778966062971,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intervertebral disc degeneration (IVDD) is a prevalent disorder associated with chronic inflammation, significantly affecting spinal health and general quality of life. This study examines the anti\u2010inflammatory properties of Friedelin (FD) and its impact on the NF\u2010\u03baB signalling pathway in relation to IVDD. In\u00a0vivo experiments utilising cervical intervertebral disc tissue from mice exhibiting cervical spine instability and in\u00a0vitro assays with nucleus pulposus (NP) cells revealed that FD treatment significantly diminished NP degeneration and inflammatory cytokine production, concurrently inhibiting NF\u2010\u03baB activation. FD triggered autophagic clearance of p65, reducing inflammatory cytokine output. This effect was mediated by selective inhibition of p65 phosphorylation, independent of IKK activity, highlighting its targeted action on NF\u2010\u03baB signalling. Moreover, FD enhanced the association between p65 and the E3 ubiquitin ligase RNF182, facilitating p65 degradation via autophagy. The findings indicate that FD mitigates IVDD by diminishing NP degradation and inflammation while also presenting a potential therapeutic strategy that targets the NF\u2010\u03baB signalling pathway through autophagic processes.<\/jats:p>","DOI":"10.1111\/jcmm.70989","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:44:16Z","timestamp":1767869056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Friedelin Ameliorates Nucleus Pulposus Inflammation by Increasing p65 Autophagic Degradation to Inhibit\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signalling Pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Kewu","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery, Shaoguan First People's Hospital Guangdong Medical University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongteng","family":"Liao","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Guangdong Medical University  Zhanjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaomou","family":"Chen","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Guangdong Medical University  Zhanjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Guangzhou Red Cross Hospital of Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Guangdong Medical University  Zhanjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Second Clinical School Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical School of Shaoguan University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical School of Shaoguan University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Joint, Sports Medicine &amp; Pediatric Orthopedics, Shaoguan First People's Hospital Guangdong Medical University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beidi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Prevention and Health Care, Shaoguan First People's Hospital Guangdong Medical University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Shaoguan First People's Hospital Guangdong Medical University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-593X","authenticated-orcid":false,"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, Shaoguan First People's Hospital Guangdong Medical University  Shaoguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-53467-z","article-title":"Genome\u2010Wide Meta\u2010Analysis Conducted in Three Large Biobanks Expands the Genetic Landscape of Lumbar Disc Herniations","volume":"15","author":"Salo V.","year":"2024","journal-title":"Nature Communications"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13541","article-title":"Notochordal Cells: A Potential Therapeutic Option for Intervertebral Disc Degeneration","volume":"57","author":"Li Y.","year":"2024","journal-title":"Cell Proliferation"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic Modifications of Inflammation in Intervertebral Disc Degeneration","volume":"87","author":"Kang L.","year":"2023","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13062-023-00395-5","article-title":"USP24\u2010Dependent Stabilization of Runx2 Recruits a p300\/NCOA3 Complex to Transactivate ADAMTS Genes and Promote Degeneration of Intervertebral Disc in Chronic Inflammation Mice","volume":"18","author":"Li X.","year":"2023","journal-title":"Biology Direct"},{"issue":"8","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom12081074","article-title":"Role of Caspase Family in Intervertebral Disc Degeneration and Its Therapeutic Prospects","volume":"12","author":"Li L.","year":"2022","journal-title":"Biomolecules"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1051606","article-title":"Biomaterials Delivery Strategies to Repair Degenerated Intervertebral Discs by Regulating the Inflammatory Microenvironment","volume":"14","author":"Xia Y.","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1150835","article-title":"Natural Products Can Modulate Inflammation in Intervertebral Disc Degeneration","volume":"14","author":"Liu Z.","year":"2023","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A New Immunometabolic Perspective of Intervertebral Disc Degeneration","volume":"18","author":"Francisco V.","year":"2022","journal-title":"Nature Reviews Rheumatology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110660","article-title":"The Role of IL\u20101\u03b2 and TNF\u2010\u03b1 in Intervertebral Disc Degeneration","volume":"131","author":"Wang Y.","year":"2020","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"4","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/BRS.0000000000000733","article-title":"Effects of Nuclear Factor Kappa B Signaling Pathway in Human Intervertebral Disc Degeneration","volume":"40","author":"Zhongyi S.","year":"2015","journal-title":"Spine"},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41413-024-00355-3","article-title":"Osteopontin Deficiency Promotes Cartilaginous Endplate Degeneration by Enhancing the NF\u2010\u03baB Signaling to Recruit Macrophages and Activate the NLRP3 Inflammasome","volume":"12","author":"Wang Y.","year":"2024","journal-title":"Bone Research"},{"issue":"23","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj3194","article-title":"Nuclear Factor \u03baB Overactivation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration","volume":"10","author":"Burt K. 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