{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:43:59Z","timestamp":1773416639843,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007543","name":"Grantov\u00e1 Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["180221"],"award-info":[{"award-number":["180221"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["LX22NPO5107"],"award-info":[{"award-number":["LX22NPO5107"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is a highly complex and multifactorial disorder in which oxidative stress acts as a key amplifying mechanism in the disease progression. Lipofuscin\u2010like pigments (LFP), end products of lipid peroxidation, reflect oxidative damage and are capable of crossing the blood\u2013brain barrier into the circulation. Thus, erythrocyte\u2010derived LFP may serve as peripheral indicators of brain\u2010specific processes. In this study, we aimed to assess the specificity of previously identified LFP for AD pathology. We analysed erythrocyte\u2010derived LFP in individuals with biomarker\u2010verified AD pathology (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940) and non\u2010AD cognitive disorders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921) across the prodromal and dementia stages, and in cognitively unimpaired individuals (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919). AD individuals showed significantly higher LFP levels compared with both healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.003) and the non\u2010AD group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.001). Furthermore, LFP levels correlated with established AD biomarkers in CSF, including amyloid\u2010beta (\n                    <jats:italic>r<\/jats:italic>\n                    &gt; \u22120.566) and phosphorylated tau 181 (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009&lt;\u20090.477). Our findings suggest that LFP may serve as potential blood\u2010based biochemical markers reflecting oxidative stress\u2013related processes associated with AD pathology.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70990","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:59:31Z","timestamp":1773028771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Specific Lipid Peroxidation Products in Erythrocytes and Their Relationship to the Pathogenesis of Alzheimer's Disease"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2317-1174","authenticated-orcid":false,"given":"Lenka","family":"Martin\u00e1kov\u00e1","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Chm\u00e1talov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Veverov\u00e1","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Jur\u00e1\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al\u017eb\u011bta","family":"Katonov\u00e1","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Lacz\u00f3","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lacz\u00f3","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine Charles University and Motol University Hospital  Prague Czech 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