{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:46:14Z","timestamp":1789577174223,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274545"],"award-info":[{"award-number":["82274545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Knee osteoarthritis (KOA), a common degenerative joint disease marked by pain, inflammation and cartilage degradation, has been increasingly associated with dysregulated innate immune signalling. Among the implicated molecular pathways, cGAS\/STING has emerged as a key modulator in both disease pathogenesis and therapeutic intervention. Quercetin, a naturally derived bioflavonoid with well\u2010documented antitumour and antioxidant activities, also exerts notable anti\u2010inflammatory and analgesic effects. This study investigated the mechanistic interaction between quercetin and the cGAS\/STING pathway in the context of pain regulation throughout KOA development. Forty\u2010eight male C57BL\/6J mice were randomly allocated into six groups: Sham, KOA, high\u2010dose quercetin (Que\u2010H), low\u2010dose quercetin (Que\u2010L), STING inhibitor (H\u2010151) and STING activator (SR\u2010717). Histological evaluations of entire knee joints were performed using haematoxylin and eosin (H&amp;E) and Safranin O\/Fast Green (SO&amp;FG) staining protocols. Serum concentrations of interleukin\u20101\u03b2 (IL\u20101\u03b2) and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were measured via ELISA. The viability of dorsal root ganglion (DRG) neurons subjected to PGE2 and quercetin was determined through the CCK\u20108 assay. Expression levels of inflammatory and nociceptive markers were assessed using Western blotting, quantitative PCR, immunofluorescence and immunohistochemistry across both in\u00a0vivo and in\u00a0vitro models. Quercetin administration led to a statistically significant reduction in peripheral inflammatory and nociceptive markers (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u20090.05), diminished pain hypersensitivity and preserved cartilage morphology in KOA mice. These outcomes correlated with the inhibition of cGAS\/STING signalling and a concomitant decrease in VEGFA, VEGFR1 and phosphorylated VEGFR1 levels (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u20090.05). By inhibiting the cGAS\/STING signalling pathway, quercetin mitigates KOA\u2010related nociception through the downregulation of VEGFA, VEGFR1 and its phosphorylated form.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70992","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:29:34Z","timestamp":1767187774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quercetin Alleviates Osteoarthritis Pain by Inhibiting Vascular Endothelial Growth Factor A Through Regulating\n                    <scp>cGAS<\/scp>\n                    \/\n                    <scp>STING<\/scp>\n                    Pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Enrui","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing Jiangsu Province China"},{"name":"Jiangsu Province Hospital of 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