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Clinical data of patients diagnosed with sepsis between January 1, 2019, and December 31, 2023, were collected from the Hospital Information System (HIS) of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University. Based on 28\u2010day outcomes, patients were divided into survival (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009146) and death (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200981) groups. Statistical analysis was performed using SPSS 20, employing univariate and multivariate logistic regression to identify prognostic risk factors. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive performance of these factors, with the area under the curve (AUC) calculated for evaluation. Although blood stasis syndrome was not included in the final model due to collinearity with critical indicators, univariate analysis demonstrated its significant prognostic value (OR\u2009=\u20092.49, 95% CI 1.199\u20135.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014), and ROC curve analysis confirmed its fundamental discriminatory capacity (AUC &gt;\u20090.5). Multivariable logistic regression identified CRP, TT, disease severity, CA and ARDS as independent risk factors for sepsis mortality. ROC analysis showed all individual indicators and the combined model had AUC &gt;\u20090.5, with the combined model achieving the highest AUC. The combined model demonstrated good stability via Hosmer\u2010Lemeshow testing (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.067). This study established CRP, TT, disease severity, CA and ARDS as independent mortality risk factors in sepsis, with the combined model showing optimal performance. It demonstrated consistency between TCM macro\u2010pattern differentiation and Western medical indicators, providing a framework for integrated prognostic models that combines both medical approaches.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71005","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:29:56Z","timestamp":1769498996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics and Prognostic Factors in Patients With Sepsis: A Retrospective Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1429-9380","authenticated-orcid":false,"given":"Mengxia","family":"Yang","sequence":"first","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Graduate School of Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8135-7376","authenticated-orcid":false,"given":"Junhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Graduate School of Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Changzhi Research Institute of Traditional Chinese Medicine  Changzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-3420","authenticated-orcid":false,"given":"Xuerui","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Clinical Diagnosis, Treatment and Research Center of Sepsis of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Clinical Diagnosis, Treatment and Research Center of Sepsis of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-9728","authenticated-orcid":false,"given":"Qingquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Clinical Diagnosis, Treatment and Research Center of Sepsis of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504\u20100781OC"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(19)32989\u20107"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010009\u20101738\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2013.764490"},{"key":"e_1_2_13_7_1","first-page":"1","article-title":"Inpatient Care for Septicemia or Sepsis: A Challenge for Patients and Hospitals","volume":"62","author":"Hall M. 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Severe Sepsis From the Perspective of \u2018Blood Stasis\u2019 Pathogenesis","volume":"22","author":"Ding H.","year":"2013","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.16138\/j.1673\u20106087.2022.04.002"},{"key":"e_1_2_13_36_1","unstructured":"J.Zhai \u201cRisk Factor Analysis for 28\u2010Day All\u2010Cause Mortality and Development of a Predictive Model for Death Risk in Patients With Sepsis \u201d Master (2024)."},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.13424\/j.cnki.mtcm.2017.01.024"},{"key":"e_1_2_13_38_1","unstructured":"Y.Zhang \u201cCorrelation Between Traditional Chinese Medicine Syndrome Types and Pyroptosis Markers (NLRP3 Caspase\u20101 GSDMD) in Sepsis Patients \u201d Master (2024)."},{"key":"e_1_2_13_39_1","unstructured":"D.Huang \u201cGinkgo Biloba Extract Inhibits the RIOK3\u2010Ferritinophagy Axis to Ameliorate Lung Epithelial Cell Damage in Sepsis and 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