{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:49:41Z","timestamp":1791859781325,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective and anti\u2010inflammatory potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aesculus hippocastanum<\/jats:italic>\n                    <\/jats:styled-content>\n                    (horse chestnut extract, HCE) in an in\u00a0vitro model of PD. Human neuroblastoma SH\u2010SY5Y cells were treated with the neurotoxin 1\u2010methyl\u20104\u2010phenylpyridinium (MPP\n                    <jats:sup>+<\/jats:sup>\n                    ) (1\u2009mM) and\/or in combination with HCE at the concentrations of 15.6, 31.2 and 62.5\u2009\u03bcg\/mL for 24\u2009h. After 24\u2009h, several analyses have been performed. Treatment with HCE at the concentrations of 31.2 and 62.5\u2009\u03bcg\/mL significantly improved cell viability following MPP\n                    <jats:sup>+<\/jats:sup>\n                    \u2010induced neurotoxicity. Furthermore, HCE effectively modulated key Parkinsonian markers by restoring tyrosine hydroxylase (TH) and reducing the number of \u03b1\u2010syn\u2010positive cells. At the same concentrations, HCE also attenuated NF\u2010\u03baB signalling pathway activation and diminished the release of pro\u2010inflammatory cytokines IL\u20101\u03b2, IL\u201017, and TNF\u2010\u03b1. Notably, HCE promoted the activation of the nuclear receptor peroxisome proliferator activated receptor gamma (PPAR\u03b3), known for its neuroprotective properties, and reduced both oxidative and nitrosative stress. Crucially, silencing of PPAR\u03b3 abolished the beneficial effects of HCE, indicating that its neuroprotective actions are mediated specifically through PPAR\u03b3 activation. Thus, these findings suggest that HCE confers neuroprotection in\u00a0vitro by regulating inflammation and oxidative stress primarily via PPAR\u03b3 modulation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71006","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:54:42Z","timestamp":1767686082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Aesculus hippocastanum<\/i>\n                    Extract Exerts Neuroprotective Effects in an MPP\n                    <sup>+<\/sup>\n                    \u2010Induced Parkinson's Disease Model via PPAR\u03b3 Activation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-9739","authenticated-orcid":false,"given":"Sarah Adriana","family":"Scuderi","sequence":"first","affiliation":[{"name":"Genetics and Pharmacogenetics Unit \u2018Gaetano Martino\u2019 University Hospital  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Ardizzone","sequence":"additional","affiliation":[{"name":"UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Casili","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Mannino","sequence":"additional","affiliation":[{"name":"Research Operative Unit of Neuropharmacology and Translational Neurosciences, Oasi Research Institute, IRCCS  Troina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Catalfamo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0742-8005","authenticated-orcid":false,"given":"Marika","family":"Lanza","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-6387","authenticated-orcid":false,"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Parkinson's Disease: Pathogenesis and Clinical Aspects","author":"Kouli A.","year":"2018"},{"issue":"1","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12974-023-02842-6","article-title":"Neuroprotective Effects of GSK\u2010343 in an In\u00a0Vivo Model of MPTP\u2010Induced Nigrostriatal Degeneration","volume":"20","author":"Mannino D.","year":"2023","journal-title":"Journal of Neuroinflammation"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.736978","article-title":"Alpha\u2010Synuclein Aggregation in Parkinson's Disease","volume":"8","author":"Srinivasan E.","year":"2021","journal-title":"Frontiers in Medicine"},{"issue":"11","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111732","article-title":"Alpha\u2010Synuclein Aggregation Pathway in Parkinson's Disease: Current Status and Novel Therapeutic Approaches","volume":"11","author":"Vidovic M.","year":"2022","journal-title":"Cells"},{"issue":"1","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in Neurodegenerative Diseases: Mechanism and Potential Therapeutic Targets","volume":"8","author":"Gao C.","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/cimb47010008","article-title":"Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders","volume":"47","author":"Kim M. E.","year":"2024","journal-title":"Current Issues in Molecular Biology"},{"issue":"6","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The Nuclear Factor NF\u2010KappaB Pathway in Inflammation","volume":"1","author":"Lawrence T.","year":"2009","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"1","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12035-012-8259-8","article-title":"Peroxisome Proliferator\u2010Activated Receptor Gamma (PPAR\u2010Gamma) and Neurodegenerative Disorders","volume":"46","author":"Chen Y. C.","year":"2012","journal-title":"Molecular Neurobiology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2741\/2802","article-title":"Mechanisms of Anti\u2010Inflammatory and Neuroprotective Actions of PPAR\u2010Gamma Agonists","volume":"13","author":"Kapadia R.","year":"2008","journal-title":"Frontiers in Bioscience"},{"issue":"11","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70081","article-title":"The Neuroprotective Mechanisms of PPAR\u2010Gamma: Inhibition of Microglia\u2010Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic\u2010Ischemic White Matter Injury","volume":"30","author":"Fang M.","year":"2024","journal-title":"CNS Neuroscience & Therapeutics"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pneurobio.2017.10.002","article-title":"Peroxisome Proliferator\u2010Activated Receptor Gamma (PPARgamma): A Master Gatekeeper in CNS Injury and Repair","volume":"163","author":"Cai W.","year":"2018","journal-title":"Progress in Neurobiology"},{"issue":"10","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9101022","article-title":"Merging the Multi\u2010Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation","volume":"9","author":"Limanaqi F.","year":"2020","journal-title":"Antioxidants"},{"issue":"10","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1007\/s12031-020-01675-9","article-title":"Correction to: Escin, a Novel Triterpene, Mitigates Chronic MPTP\/P\u2010Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis","volume":"70","author":"Selvakumar G. P.","year":"2020","journal-title":"Journal of Molecular Neuroscience"},{"issue":"10","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164365","article-title":"Molecular Mechanism for Cellular Response to Beta\u2010Escin and Its Therapeutic Implications","volume":"11","author":"Domanski D.","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s12031-014-0303-x","article-title":"Escin, a Novel Triterpene, Mitigates Chronic MPTP\/p\u2010Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis","volume":"55","author":"Selvakumar G. P.","year":"2015","journal-title":"Journal of Molecular Neuroscience"},{"issue":"9","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70810","article-title":"Anti\u2010Apoptotic Effects of Escin on \n                     Porphyromonas gingivalis\n                  \u2010Derived Lipopolysaccharide\u2010Induced Injury in SH\u2010SY5Y Cells","volume":"15","author":"Sun Y.","year":"2025","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"issue":"11","key":"e_1_2_12_18_1","article-title":"Horse Chestnut Seed Extract for Chronic Venous Insufficiency","volume":"11","author":"Pittler M. H.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7326\/ACPJC-2006-145-1-020","article-title":"Review: Horse Chestnut Seed Extract Is Effective for Symptoms of Chronic Venous Insufficiency","volume":"145","author":"Kahn S. R.","year":"2006","journal-title":"ACP Journal Club"},{"issue":"8","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25081917","article-title":"Aesculus hippocastanum L. Extract Does Not Induce Fibroblast to Myofibroblast Conversion but Increases Extracellular Matrix Production In\u00a0Vitro Leading to Increased Wound Tensile Strength in Rats","volume":"25","author":"Kov\u00e1\u010d I.","year":"2020","journal-title":"Molecules"},{"issue":"23","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312988","article-title":"Ulva pertusa\n                   Modulated Colonic Oxidative Stress Markers and Clinical Parameters: A Potential Adjuvant Therapy to Manage Side Effects During 5\u2010FU Regimen","volume":"25","author":"Repici A.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ptr.4688","article-title":"Antiproliferative and Antiangiogenic Properties of Horse Chestnut Extract","volume":"27","author":"Mojzisova G.","year":"2013","journal-title":"Phytotherapy Research"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neuro.2021.10.003","article-title":"Baicalein Protects Against MPP(+)\/MPTP\u2010Induced Neurotoxicity by Ameliorating Oxidative Stress in SH\u2010SY5Y Cells and Mouse Model of Parkinson's Disease","volume":"87","author":"Song Q.","year":"2021","journal-title":"Neurotoxicology"},{"issue":"8","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/ph17081102","article-title":"EZH2 Inhibition to Counteract Oral Cancer Progression Through Wnt\/Beta\u2010Catenin Pathway Modulation","volume":"17","author":"Campolo M.","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"23","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.3390\/cancers16233936","article-title":"Casein Kinase 2 Inhibitor, CX\u20104945, Induces Apoptosis and Restores Blood\u2010Brain Barrier Homeostasis in In\u00a0Vitro and In\u00a0Vivo Models of Glioblastoma","volume":"16","author":"Bova V.","year":"2024","journal-title":"Cancers"},{"issue":"5","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom15050677","article-title":"PI3K\/mTOR Signaling Pathway Dual Inhibition for the Management of Neuroinflammation: Novel Insights From In\u00a0Vitro Models","volume":"15","author":"Ardizzone A.","year":"2025","journal-title":"Biomolecules"},{"issue":"3","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom11030352","article-title":"Beneficial Effect of Tempol, a Membrane\u2010Permeable Radical Scavenger, on Inflammation and Osteoarthritis in In\u00a0Vitro Models","volume":"11","author":"Calabrese G.","year":"2021","journal-title":"Biomolecules"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105604","article-title":"Mitigating Neuroinflammation in Parkinson's Disease: Exploring the Role of Proinflammatory Cytokines and the Potential of Phytochemicals as Natural Therapeutics","volume":"170","author":"Sharma P.","year":"2023","journal-title":"Neurochemistry International"},{"issue":"1","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of Neuroinflammation in Neurodegeneration Development","volume":"8","author":"Zhang W.","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"18","key":"e_1_2_12_30_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11182908","article-title":"Neuroinflammation and Parkinson's Disease\u2014From Neurodegeneration to Therapeutic Opportunities","volume":"11","author":"Ara\u00fajo B.","year":"2022","journal-title":"Cells"},{"issue":"11","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.3390\/ijms23115938","article-title":"An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases","volume":"23","author":"Teleanu D. M.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-811X-11-34","article-title":"Complexity of Dopamine Metabolism","volume":"11","author":"Meiser J.","year":"2013","journal-title":"Cell Communication and Signaling"},{"issue":"1","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s12035-021-02596-3","article-title":"An Update on the Critical Role of \u03b1\u2010Synuclein in Parkinson's Disease and Other Synucleinopathies: From Tissue to Cellular and Molecular Levels","volume":"59","author":"Serratos I. N.","year":"2022","journal-title":"Molecular Neurobiology"},{"issue":"3","key":"e_1_2_12_34_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha\u2010Synuclein in Parkinson's Disease and Other Synucleinopathies: From Overt Neurodegeneration Back to Early Synaptic Dysfunction","volume":"14","author":"Calabresi P.","year":"2023","journal-title":"Cell Death & Disease"},{"key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12640-019-00147-2","article-title":"NF\u2010\u03baB\u2010Mediated Neuroinflammation in Parkinson's Disease and Potential Therapeutic Effect of Polyphenols","volume":"37","author":"Singh S. S.","year":"2020","journal-title":"Neurotoxicity Research"},{"issue":"1","key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10787-024-01635-4","article-title":"Stimulation, Regulation, and Inflammaging Interventions of Natural Compounds on Nuclear Factor Kappa B (NF\u2010kB) Pathway: A Comprehensive Review","volume":"33","author":"Kannan G.","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"1","key":"e_1_2_12_37_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12974-022-02457-3","article-title":"SUN11602, a bFGF Mimetic, Modulated Neuroinflammation, Apoptosis and Calcium\u2010Binding Proteins in an In\u00a0Vivo Model of MPTP\u2010Induced Nigrostriatal Degeneration","volume":"19","author":"Ardizzone A.","year":"2022","journal-title":"Journal of Neuroinflammation"},{"issue":"1","key":"e_1_2_12_38_1","article-title":"PPAR\u03b3 and Oxidative Stress: Con (\u03b2) Catenating NRF2 and FOXO","volume":"2012","author":"Polvani S.","year":"2012","journal-title":"PPAR Research"},{"key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2741\/2802","article-title":"Mechanisms of Anti\u2010Inflammatory and Neuroprotective Actions of PPAR\u2010Gamma Agonists","volume":"13","author":"Kapadia R.","year":"2008","journal-title":"Frontiers in Bioscience: A Journal and Virtual Library"},{"issue":"2","key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1471-4159.2008.05388.x","article-title":"PPAR: A Therapeutic Target in Parkinson's Disease","volume":"106","author":"Chaturvedi R. K.","year":"2008","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043201","article-title":"Development of PPAR\u03b3 Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate","volume":"24","author":"Pizcueta P.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bcp.2014.07.018","article-title":"Natural Product Agonists of Peroxisome Proliferator\u2010Activated Receptor Gamma (PPAR\u03b3): A Review","volume":"92","author":"Wang L.","year":"2014","journal-title":"Biochemical Pharmacology"},{"issue":"7","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbadis.2008.12.006","article-title":"Oxidative and Nitrosative Stress in Parkinson's Disease","volume":"1792","author":"Tsang A. H.","year":"2009","journal-title":"Biochimica et Biophysica Acta, Molecular Basis of Disease"},{"issue":"2","key":"e_1_2_12_44_1","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12020268","article-title":"The Key Roles of ROS and RNS as a Signaling Molecule in Plant\u2013Microbe Interactions","volume":"12","author":"Khan M.","year":"2023","journal-title":"Antioxidants"},{"issue":"5","key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cnr.2006.09.006","article-title":"Neuroinflammation, Oxidative Stress, and the Pathogenesis of Parkinson's Disease","volume":"6","author":"Mosley R. L.","year":"2006","journal-title":"Clinical Neuroscience Research"},{"issue":"1","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9971885","article-title":"Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders","volume":"2021","author":"Akanji M. A.","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_12_47_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2024.1419108","article-title":"Parkinson's Disease Models and Death Signaling: What Do We Know Until Now?","volume":"18","author":"Pedr\u00e3o L. F. A.","year":"2024","journal-title":"Frontiers in Neuroanatomy"},{"issue":"22","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications","volume":"13","author":"Mustafa M.","year":"2024","journal-title":"Cells"},{"key":"e_1_2_12_49_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114076","article-title":"Revealing Rutaecarpine's Promise: A Pathway to Parkinson's Disease Relief Through PPAR Modulation","volume":"147","author":"Wang Y.","year":"2025","journal-title":"International Immunopharmacology"},{"key":"e_1_2_12_50_1","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.70111","article-title":"Neuroprotective Effect of Abscisic Acid on MPTP\u2010Induced Parkinson's Disease in Mice","volume":"69","author":"Yang Z.","year":"2025","journal-title":"Molecular Nutrition & Food Research"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:54:49Z","timestamp":1767686089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jcmm.71006"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71006","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71006"}}