{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:44:49Z","timestamp":1789497889086,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ferroptosis, an iron\u2010dependent regulated necrosis driven by redox imbalance, plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Kaempferol (KF), a bioactive flavonoid from\n                    <jats:italic>Polygonati Rhizoma<\/jats:italic>\n                    , exhibits anti\u2010ferroptotic properties in lipid peroxidation disorders, yet its molecular mechanism against cigarette smoke extract (CSE)\u2010induced ferroptosis in human bronchial epithelial cells (BEAS\u20102B) remains to be fully elucidated. Using in\u00a0vitro models of CSE\u2010induced injury, we observed that KF restored cell viability and attenuated cytotoxicity by restoring redox equilibrium\u2014significantly elevating glutathione (GSH) while reducing malondialdehyde (MDA) and labile iron pool (Fe\n                    <jats:sup>2+<\/jats:sup>\n                    ) levels. Mechanistically, KF suppressed ferritinophagy via nuclear receptor coactivator 4 (NCOA4) inhibition and rescued glutathione peroxidase 4 (GPx4) activity, thereby blocking lipid peroxidation cascades. These effects were mediated through Nrf2\u2010dependent transcriptional activation, counteracting CSE\u2010triggered Nrf2 pathway dysregulation. Our findings reveal that KF mitigates COPD progression by coordinately targeting the Nrf2\/NCOA4\/GPx4 axis to inhibit ferroptosis, providing a novel therapeutic strategy for oxidative stress\u2010driven pulmonary diseases.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71010","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:30:07Z","timestamp":1767187807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Kaempferol Mitigates\n                    <scp>CSE<\/scp>\n                    \u2010Induced Lung Injury and Epithelial Cell Ferroptosis via Modulating Nrf2\/\n                    <scp>NCOA4<\/scp>\n                    \/\n                    <scp>GPx4<\/scp>\n                    Axis"],"prefix":"10.1111","volume":"30","author":[{"given":"Fengri","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Central People's Hospital of Zhanjiang  Zhanjiang Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Zhaoqing Medical College  Zhaoqing Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Zhanjiang Institute of Clinical Medicine, Zhanjiang Central Hospital, Guangdong Medical University  Zhanjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhennan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Central People's Hospital of Zhanjiang  Zhanjiang Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aibin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical 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