{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:11:27Z","timestamp":1770959487213,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2023H010"],"award-info":[{"award-number":["LH2023H010"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["LPHGRD 2023\u2010006"],"award-info":[{"award-number":["LPHGRD 2023\u2010006"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The AT\u2010Rich Interaction Domain (ARID) family plays critical roles in malignancies. Although numerous members have been shown to influence cancer processes, there is a lack of a general understanding of the ARID family in colon cancer. To address this gap, we used bioinformatic technologies to investigate the role of the ARID family as a whole and to identify the crucial member. Subsequently, cell growth assays, transwell assays, and animal models were employed to validate the key member's effect on colon cancer growth and metastasis. Furthermore, bioinformatics and immunohistochemistry were utilised to explore the potential mechanisms and evaluate the efficacy of a targeted intervention strategy. Our results showed that the ARID family was upregulated in colon cancer, with ARID3A being the main component that promoted colon cancer development. Specifically, ARID3A enhanced colon cancer cell proliferation, migration, and invasion both in\u00a0vivo and in\u00a0vitro. Mechanistically, this promotional effect could be associated with ARID3A promoting PGE2 synthesis and triggering macrophage infiltration. Notably, aspirin treatment reduced the PGE2 level, which significantly inhibited the malignant behaviour of ARID3A\u2010overexpressing cells. In conclusion, ARID3A was a key member of the ARID family in the development of colon cancer. ARID3A was an underlying biomarker for aspirin administration.<\/jats:p>","DOI":"10.1111\/jcmm.71038","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T03:50:37Z","timestamp":1769658637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ARID3A<\/scp>\n                    Dysregulation Drives Colon Cancer Progression and Enhances Responsiveness to Aspirin"],"prefix":"10.1111","volume":"30","author":[{"given":"Jiade","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurobiology School of Basic Medical, Harbin Medical University  Harbin Heilongjiang P.R. China"},{"name":"Department of Biotherapy Center Harbin Medical University Cancer Hospital  Harbin P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Basic Medical, Harbin Medical University  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-3359","authenticated-orcid":false,"given":"Quanfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ordos Central Hospital  Ordos Inner Mongolia P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yungaowa","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ordos Central Hospital  Ordos Inner Mongolia P.R. 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