{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:41:03Z","timestamp":1780983663322,"version":"3.54.1"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is a progressive neurodegenerative disorder, posing a global health challenge. It affects millions of people, causing cognitive decline and a heavy burden on healthcare systems. Neuroinflammation is a key pathological feature of AD, often associated with the dysregulation of microRNAs such as hsa\u2010miR\u2010146a\u20105p. WGX50 (N\u2010[2\u2010(3,4\u2010Dimethoxy\u2010phenyl)\u2010ethyl]\u20103\u2010phenyl\u2010acrylamide), a small molecule derived from\n                    <jats:italic>Zanthoxylum bungeanum<\/jats:italic>\n                    Maxim, has antioxidant and anti\u2010inflammatory activities. While WGX50 demonstrates potent inhibition of neuroinflammation, its poor blood\u2013brain barrier permeability may be improved using targeted delivery strategies. The current study aimed to design a novel nanoconjugate of WGX50 and curcumin with gold nanoparticles (AuNPs) to observe its therapeutic effects in a rat model. All nanoconjugates were synthesised as targeted (Cys\u2010capped AuNPs with WGX50\u2010insulin and curcumin\u2010insulin) and non\u2010targeted (without insulin). Immunohistochemical analysis revealed that both non\u2010targeted (WGX50\u2010NT) and targeted (WGX50\u2010T) therapies have a significant effect in the rat model, with WGX50\u2010T showing a more pronounced effect. The histopathology results of WGX50 and WGX50\u2010T showed an approximate 80%\u201390% reduction in A\u03b2 plaque deposition. The treatment with both curcumins targeted (C\u2010T) and non\u2010targeted (C\u2010NT) formulations led to a significant reduction in A\u03b2 levels in AD rats. Fluorescence microscopy confirmed that targeted delivery was more effective, potentially leading to better therapeutic outcomes. The expression levels of hsa\u2010miR\u2010146a\u20105p showed differential expression levels with targeted treatments correlating with lower expression levels, suggesting a role in modulating neuroinflammation and immune responses. Overall, these findings highlight the potential of targeted drug delivery systems in enhancing the efficacy of AD treatments.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71045","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:21:20Z","timestamp":1770366080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted Nanodelivery of\n                    <scp>WGX50<\/scp>\n                    and Curcumin via Gold Nanoparticles for Alzheimer's Therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"Madeeha Shahzad","family":"Lodhi","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Maisam","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Science China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-2133","authenticated-orcid":false,"given":"Muhammad Tahir","family":"Khan","sequence":"additional","affiliation":[{"name":"International Center for Interdisciplinary Research in Sciences (ICIRS) The University of Lahore  Lahore Pakistan"},{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis Research, Department of Clinical Laboratory, Guangzhou Chest Hospital, Institute of Tuberculosis Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Bibi","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic &amp; Developmental Sciences and School of Life Sciences and Biotechnology Shanghai Jiao Tong University  Shanghai P.R. 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