{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:11:18Z","timestamp":1770959478551,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470483"],"award-info":[{"award-number":["82470483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Percutaneous coronary intervention (PCI) enables coronary revascularisation and restores haemodynamic stability but also carries risks of delayed complications including in\u2010stent restenosis (ISR), a chronic progressive disease with endovascular damage after PCI, which compromises the long\u2010term efficacy of PCI. Currently, the main treatment strategies for ISR include interventional and drug therapies. From the era of using aspirin as a single antiplatelet agent to the \u2018gold standard\u2019 era of dual antiplatelet therapy, the risk of ISR after PCI has been reduced. However, long\u2010term use of antiplatelet drugs inevitably causes a series of side effects such as gastrointestinal mucosal damage and bleeding, which have become key limiting factors in clinical treatment. Saponin natural products have been used to mitigate ISR progression by targeting platelet dysfunction. Specifically, these compounds directly bind to platelet membrane receptors, block ligand\u2013receptor interactions, inhibit the secretion of \u03b1\u2010granule and dense\u2010granule contents, regulate intracellular signalling pathways and platelet metabolism, inhibit release of inflammatory mediators, and suppress platelet aggregation. This article reviews the progresses on the application of the active components in saponin natural products to inhibit platelet activation in the development of ISR after PCI, aiming to provide a superior approach for the comprehensive treatment of ISR after PCI.<\/jats:p>","DOI":"10.1111\/jcmm.71056","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:16:27Z","timestamp":1770956187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention of In\u2010Stent Restenosis After\n                    <scp>PCI<\/scp>\n                    by Saponin Natural Products: Inhibition of Platelet Activation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0383-2027","authenticated-orcid":false,"given":"Xueli","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Cardiology Tai'an 88 Hospital  Taian Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tai'an 88 Hospital  Taian Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tai'an 88 Hospital  Taian Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tai'an 88 Hospital  Taian Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Wujiang Branch of Suzhou Central Blood Station  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-294X","authenticated-orcid":false,"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Suzhou Ninth Hospital Affiliated to Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytae233"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2021.1856657"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020206"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.05.016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.06.032"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1815"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071916"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24132443"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2017.09.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.07.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.005"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2011.01.015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114521004852"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153286"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002006\u2010x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010020\u201002213\u20109"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.249"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.088"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010016\u20109877\u2010z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01099"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109814"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010020\u201001440\u20107"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.10.003"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2024.08.004"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113574"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.13193\/j.issn.1673\u20107717.2017.11.015"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0000000000000752"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.08.001"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153288"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.19\u20100037"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395\u2010021\u201000870\u2010y"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12928\u2010020\u201000734\u20107"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101731663"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.08.007"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239\u2010010\u20100466\u20104"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.5114\/aic.2022.115631"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32836222ec"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.11.003"},{"issue":"8","key":"e_1_2_12_42_1","first-page":"21","article-title":"Study on Antiplatelet and Anticoagulant Mechanism of Sanqi","volume":"34","author":"Zhu X. Y.","year":"2021","journal-title":"Western Journal of Traditional Chinese Medicine"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.15975\/j.cnki.gsyy.2012.01.013"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.07.038"},{"issue":"9","key":"e_1_2_12_45_1","first-page":"1315","article-title":"Experimental Research on the Protective Effect of Panax notoginseng Saponins on the Gastric Mucosa and the Anti\u2010Platelet Effect of Aspirin Based on Arachidonic Acid Metabolic Pathway","volume":"17","author":"Wang W. T.","year":"2019","journal-title":"Chinese Journal of Integrative Medicine on Cardio\u2010Cerebrovascular Disease"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.053"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431x20199085"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24203723"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2012.01967.x"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.13412\/j.cnki.zyyl.2017.01.027"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201014\u20101434"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2016.1200008"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.123.318341"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.13422\/j.cnki.syfjx.20241018"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15689"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.112.250720"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154880"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201001\u2010261206"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.03.010"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1157\/13108766"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102021\u20100817"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199067"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010019\u20100709\u20106"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2019.05.005"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/204840"},{"key":"e_1_2_12_66_1","volume-title":"A Cheminformatics Analysis of Natural Products From Different Biological Sources","author":"Liu Y.","year":"2020"},{"issue":"1","key":"e_1_2_12_67_1","first-page":"19","article-title":"Study on the Quality Markers of Panax notoginseng Powder Based on Its Function of Promoting Blood Circulation","volume":"24","author":"Li X.","year":"2022","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica\u2010World Science and Technology"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239\u2010019\u201001945\u20103"},{"issue":"12","key":"e_1_2_12_69_1","first-page":"1919","article-title":"Compound Danshen Dripping Pills Improves Clinical Efficacy in Post\u2010PCI Patients With Aspirin Resistance","volume":"18","author":"Lu Y.","year":"2020","journal-title":"Chinese Journal of Integrative Medicine on Cardio\u2010Cerebrovascular Diseases"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.14148\/j.issn.1672\u20100482.2016.0425"},{"issue":"18","key":"e_1_2_12_71_1","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1016\/S0021-9258(17)33098-3","article-title":"Purification of the Cyclooxygenase That Forms Prostaglandins. Demonstration of Two Forms of Iron in the Holoenzyme","volume":"251","author":"Hemler M.","year":"1976","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801018R"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010021\u201000424\u20103"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.71.2.332"},{"issue":"12","key":"e_1_2_12_75_1","first-page":"2317","article-title":"Research on the Anti\u2010Platelet Effects of Panax Notoginseng Saponins Combined With Aspirin Based on Molecular Docking and in Vivo Experiments","volume":"23","author":"Sun Z. X.","year":"2020","journal-title":"Frontiers in Pharmaceutical Sciences"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20170901.004"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:42:15Z","timestamp":1770957735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jcmm.71056"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71056","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71056"}}