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Jaceidin, a compound derived from flavonoids abundant in common fruits and vegetables, has attracted interest for its potential anti\u2010cancer properties. Nevertheless, the specific effects of jaceidin on melanoma cells remained unclear before this study. Here, we examined the impact of jaceidin on two metastatic melanoma cell lines, HMY\u20101 and A2058. Our results demonstrate that jaceidin exerts a significant anti\u2010metastatic effect against both cell lines. This inhibitory action involved modulating the phosphorylation of extracellular signal\u2010regulated kinase and c\u2010Jun N\u2010terminal kinase, as well as suppressing proteins associated with epithelial\u2010mesenchymal transition. Furthermore, jaceidin reduced the expression of extracellular matrix degradation proteins MMP\u20102 and cathepsins A. These compelling findings suggest that jaceidin warrants further investigation as a potential therapeutic agent for melanoma.<\/jats:p>","DOI":"10.1111\/jcmm.71068","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:36:45Z","timestamp":1772980605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Jaceidin Suppresses Melanoma Metastasis by Modulating\n                    <scp>ERK<\/scp>\n                    ,\n                    <scp>JNK<\/scp>\n                    Pathways and Extracellular Matrix Degradation Proteins"],"prefix":"10.1111","volume":"30","author":[{"given":"Mu\u2010Kuei","family":"Shieu","sequence":"first","affiliation":[{"name":"Department of Dermatology Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ju","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of 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