{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:20:58Z","timestamp":1787170858843,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pituitary adenomas (PAs) are common intracranial tumours, and invasiveness in nonfunctioning invasive pituitary adenomas (NIPAs) predicts poor prognosis. The molecular mechanisms driving this phenotype remain unclear. This study explored the role of nuclear receptor subfamily 3 group C member 1 (NR3C1) in NIPA invasiveness and its regulation of Wnt signalling. mRNA expression profiles of 32 PA samples were generated by RNA\u2010seq, and proteomic data from 19 samples were obtained by mass spectrometry. Immune\u2010related differentially expressed genes (DEGs) were retrieved from GeneCards. Weighted gene coexpression network analysis identified modules and hub genes linked to invasiveness, while machine learning methods (support vector machine, LASSO, random forest) prioritised key genes. Gene set enrichment analysis (GSEA) assessed pathways associated with candidate gene expression. NR3C1 expression and function were validated by immunohistochemistry, Western blotting and invasion assays. Integration of transcriptomic, proteomic and immune\u2010related datasets yielded 11 overlapping genes, with NR3C1 emerging as the top candidate. NR3C1 was significantly upregulated in NIPAs and demonstrated good discriminatory power by ROC analysis. GSEA associated high NR3C1 expression with Wnt pathway activation. Functional experiments confirmed that NR3C1 overexpression enhances the invasive capacity of PA cells. NR3C1 promotes the invasive phenotype of NIPAs by activating Wnt signalling. These findings suggest NR3C1 as a potential biomarker and therapeutic target for invasive pituitary adenomas.<\/jats:p>","DOI":"10.1111\/jcmm.71097","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:03:23Z","timestamp":1774843403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas"],"prefix":"10.1111","volume":"30","author":[{"given":"Xiaoping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University  Fuzhou City Fujian Province China"},{"name":"Department of Neurosurgery Xiamen Hospital of Traditional Chinese Medicine  Xiamen Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiamen Hospital of Traditional Chinese Medicine  Xiamen Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiamen Hospital of Traditional Chinese Medicine  Xiamen Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3668-9515","authenticated-orcid":false,"given":"Yuanxiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University  Fuzhou City Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2020.04.002"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0602"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.3.FOCUS20114"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040977"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac703"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2021.598887"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1079777"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14729"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.785050"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa449"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-022-01211-5"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020164"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-021-00321-9"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac150"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.04.001"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-024-10294-2"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04560-2"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05164-0"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1124646"},{"issue":"14","key":"e_1_2_14_21_1","first-page":"1581","article-title":"Phthalate Esters and Dexamethasone Synergistically Activate Glucocorticoid Receptor","volume":"55","author":"Leng Y.","year":"2020","journal-title":"Journal of Environmental Science and Health. 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