{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:00:42Z","timestamp":1776852042654,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["MFAG 2022\u2010ID.27606"],"award-info":[{"award-number":["MFAG 2022\u2010ID.27606"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG 2020\u2010ID.24365"],"award-info":[{"award-number":["IG 2020\u2010ID.24365"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG25739"],"award-info":[{"award-number":["IG25739"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1\u2010driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in NEAT1\u2010KD AMO1 cells and upregulated in NEAT1\u2010overexpressing AMO1 cells (AMO1\u2010OVX). The co\u2010expression of NEAT1 and the targets was validated in MM patients (GSE116294, GSE13591, GSE6477, CoMMpass), and in NEAT1\u2010KD NCI\u2010H929, LP1, and KMS27 cell lines, showing for all targets a consistent downregulation, resembling that of NEAT1. The functional implication of the ceRNA network was explored by functional enrichment analyses of the 40 targets, identifying 78 significant gene sets, 17 of which were found significantly enriched by GSEA analysis in at least one experimental condition among NEAT1\u2010KD LP1, NCI\u2010H929, and KMS27 cells, AMO1\u2010OVX cells, or the extreme quartiles of NEAT1 expression in the CoMMpass dataset. Noteworthy, the cell cycle gene set was validated in 5 out of 6 conditions tested, suggesting that in MM the impact of NEAT1 upregulation on the cell cycle, experimentally demonstrated in our earlier publications, may be attributable, at least partially, to ceRNA mechanisms.<\/jats:p>","DOI":"10.1111\/jcmm.71123","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:51:08Z","timestamp":1775191868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma"],"prefix":"10.1111","volume":"30","author":[{"given":"Domenica","family":"Ronchetti","sequence":"first","affiliation":[{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Traini","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Silvestris","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Fabbiano","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Devecchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Innovation Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Torricelli","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Research Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Puccio","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Research Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Craparotta","sequence":"additional","affiliation":[{"name":"Computational Oncology Unit, Experimental Oncology Department Mario Negri IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bolis","sequence":"additional","affiliation":[{"name":"Computational Oncology Unit, Experimental Oncology Department Mario Negri IRCCS  Milan Italy"},{"name":"Bioinformatics Core Unit Institute of Oncology Research (IOR)  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Piva","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Neri","sequence":"additional","affiliation":[{"name":"Scientific Directorate Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Agnelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Innovation Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"},{"name":"Department of Medical Oncology Fondazione IRCCS Istituto Nazionale Tumori  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Passamonti","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"},{"name":"Hematology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Bolli","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"},{"name":"Hematology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Taiana","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3257"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.944299"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000566\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1672\u20100229(08)60044\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.20"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071574"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010018\u20100116\u2010y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201024701\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12329"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010019\u20100542\u20105"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna6030026"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281167"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.62728"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22008"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2024.2422153"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173752"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.10.026"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20100418\u2010z"},{"key":"e_1_2_11_21_1","first-page":"5815","article-title":"Identification of Novel Survival\u2010Related lncRNA\u2010miRNA\u2010mRNA Competing Endogenous RNA Network Associated With Immune Infiltration in Colorectal Cancer","volume":"13","author":"Li J.","year":"2021","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1071"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1248"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040782"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.53"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20668"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6151"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16051033"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001468\u20108"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27653"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010025\u201003869\u20102"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.285470"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010023\u201011084\u2010x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201023\u20100282"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13426"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28706"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.201301"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010021\u201001747\u2010z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010025\u201002510\u20106"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.2.1202"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04\u201008\u20100689"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301765200"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010015\u20100129\u20101"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200204155"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028456"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.07.012"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:13:26Z","timestamp":1776849206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jcmm.71123"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71123","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71123"}}