{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:39Z","timestamp":1787015379095,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000450988"],"award-info":[{"award-number":["RS\u20102024\u201000450988"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parkinson's disease (PD) is characterised by progressive neurodegeneration and is marked by the formation of Lewy bodies, which are intracellular aggregates primarily composed of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010synuclein. Mitochondrial dysfunction and impaired protein degradation pathways are thought to play critical roles in PD progression, contributing to the loss of dopaminergic neurons in the\n                    <jats:italic>substantia nigra<\/jats:italic>\n                    . Phosphorylation of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010synuclein has been shown to promote its aggregation, underscoring its potential role in disease progression. Parkin, an E3 ubiquitin ligase, is widely regarded as a pleiotropic neuroprotective protein that modulates the mitochondrial quality control, as well as metabolic turnover and the accumulation of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010synuclein. Death\u2010associated protein kinase 1 (DAPK1), which is involved in the regulation of apoptosis and autophagy, has recently emerged as an important factor in neurodegeneration. While DAPK1 has been implicated in Alzheimer's disease through its role in tau aggregation and amyloid\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    production, our findings suggest that DAPK1 may also influence PD\u2010related pathways by phosphorylating parkin at Ser136 and Ser198. This phosphorylation promotes the mitochondrial transport of parkin, enhancing interaction with mitochondria\u2010localised E3 ubiquitin ligase MITOL and consequently leading to the degradation of parkin. Given the neuroprotective role of parkin, its reduction increases the vulnerability of neurons to 6\u2010hydroxydopamine\u2010induced toxicity, potentially contributing to decreased neuronal survival. Together, these findings suggest that DAPK1 functions as a previously unrecognised modulator of parkin and could potentially influence PD\u2010related neurodegenerative processes. This pathway may provide a mechanistic link between mitochondrial dysfunction,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010synuclein pathology and neuronal cell death.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71132","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T03:43:56Z","timestamp":1775533436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>DAPK1<\/scp>\n                    \u2010Mediated Parkin Inactivation Enhances Neurotoxicity via\n                    <scp>MITOL<\/scp>\n                    \u2010Dependent Degradation"],"prefix":"10.1111","volume":"30","author":[{"given":"Chul Hong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Systems Biology, College of Life Science and Biotechnology Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyuk","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Life Science and Biotechnology Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-3849","authenticated-orcid":false,"given":"Kwang Chul","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, College of Life Science and Biotechnology Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101789.2007.00803.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600933200"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb748"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00042"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20303"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3028"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200809125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13392"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000676\u20107"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13164"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22828"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142615"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3983"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010130377"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.12.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5607\/en20014"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1552"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.204"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.11.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135718"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949097"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000298"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1428817"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14144"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200611128"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(05)00012\u20102"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(00)81382\u20103"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5338.687"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(03)00050\u20109"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20198"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9233749"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71132","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:13:51Z","timestamp":1776849231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jcmm.71132"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71132","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.64898\/2026.01.07.698295","asserted-by":"object"}]},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71132"}}