{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:37:48Z","timestamp":1777117068617,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sarcopenia is a muscle disorder characterized by progressive loss of muscle mass, strength and function with ageing. Non\u2010coding RNAs have been reported to be involved in the progression of sarcopenia. The current study aimed to investigate the pathogenesis of sarcopenia. Based on the bioinformatics analyses and RT\u2010qPCR validation, the lncRNA A430093F15Rik was selected as the potential target involved in sarcopenia progression. Its expression level was up\u2010regulated with ageing in mice but down\u2010regulated with myogenesis in C2C12 cells. Modulating A430093F15Rik showed that the inhibition of the lncRNA contributed to the attenuation of sarcopenia such as increased cell viability and enhanced myogenesis, while the overexpression promoted disease progression. The downstream effector of A430093F15Rik, miR\u2010337\u20103p, showed opposite function to the lncRNA, while Fam168a showed similar effects. Moreover, modulating both factors also confirmed their distinct roles during sarcopenia progression. The dual luciferase and RNA pulldown assays then verified the direct binding between A430093F15Rik and miR\u2010337\u20103p, and miR\u2010337\u20103p and Fam168a, representing a ceRNA regulatory mechanism between A430093F15Rik, miR\u2010337\u20103p and Fam168a. The current study identified a novel lncRNA, A430093F15Rik, that is involved in the progression of sarcopenia by acting as a competitive endogenous RNA (ceRNA) to sponge miR\u2010337\u20103p and regulate the expression of Fam168a.<\/jats:p>","DOI":"10.1111\/jcmm.71133","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:32:54Z","timestamp":1776342774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibited Differentiation and Growth of Myocyte Associated With Sarcopenia: The Key Role of the lncRNA A430093F15Rik\/microRNA\u2010337\u20103p\/Fam168a Pathway"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5368-8764","authenticated-orcid":false,"given":"Qing","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Putuo People's Hospital, School of Medicine, Tongji University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Putuo People's Hospital, School of Medicine, Tongji University  Shanghai People's Republic of China"},{"name":"Department of General Surgery Putuo People's Hospital, School of Medicine, Tongji University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Putuo People's Hospital, School of Medicine, Tongji University  Shanghai People's Republic of China"},{"name":"Department of General Surgery Putuo People's Hospital, School of Medicine, Tongji University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Putuo People's Hospital, School of Medicine, Tongji University  Shanghai People's Republic of China"},{"name":"Department of General Surgery Shanghai Sixth People's Hospital  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2011.03.003"},{"key":"e_1_2_11_3_1","first-page":"177","article-title":"Clinical Definition of Sarcopenia","volume":"11","author":"Santilli V.","year":"2014","journal-title":"Clinical Cases in Mineral and Bone Metabolism"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-024-01493-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101270"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00249.2004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2017.08.098"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134759"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00167"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2772"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211134"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1143-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.844092"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3074"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2521"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2017.03.003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8090988"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00077.2007"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045328"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00548"},{"key":"e_1_2_11_22_1","first-page":"397","volume-title":"InBioinformatics and Computational Biology Solutions Using R and Bioconductor 2005","author":"Smyth G. 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