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Transcriptomic studies of EPC and benign eccrine poroma (EP) have identified recurrent fusions and expression changes, but differences distinguishing malignant EPC from benign EP are unclear. RNA was extracted from formalin\u2010fixed, paraffin\u2010embedded (FFPE) samples (13 EPCs and 49 EPs) from Helsinki Biobank and Finnish Clinical Biobank Tampere. RNA sequencing characterized transcriptomic profiles. Histopathological features were assessed on haematoxylin\u2013eosin\u2013stained sections, and fusion genes were evaluated by NUT and YAP1 immunohistochemistry. EPCs and EPs clustered into two transcriptomic groups regardless of tumour subtype, primarily distinguished by differential expression of genes involved in skin metabolism. The metabolism\u2010high group showed higher expression of genes associated with immune\u2010related processes, mesothelin, and Ras\u2010MAPK signalling. The metabolism\u2010low group contained a subgroup enriched for Hedgehog pathway\u2013associated genes, such as\n                    <jats:italic>GLI1<\/jats:italic>\n                    ,\n                    <jats:italic>GLI2<\/jats:italic>\n                    ,\n                    <jats:italic>HHIP<\/jats:italic>\n                    ,\n                    <jats:italic>LRP2<\/jats:italic>\n                    , and\n                    <jats:italic>PTCH2<\/jats:italic>\n                    . All samples with the\n                    <jats:italic>YAP1\u2013NUTM1<\/jats:italic>\n                    fusion pattern belonged to the metabolism\u2010low group and showed elevated\n                    <jats:italic>NUTM1<\/jats:italic>\n                    expression in the heatmap. RNA sequencing revealed transcriptomic subgroups in EPC\/EP partly linked to fusions. The results underscore the necessity for further investigation into the disrupted signalling pathways, which may facilitate the development of targeted therapies.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71140","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:15:21Z","timestamp":1776226521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>RNA<\/scp>\n                    \u2010Sequencing Reveals Two Subgroups of Eccrine Porocarcinomas and Poromas"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3982-9038","authenticated-orcid":false,"given":"Maya","family":"Puttonen","sequence":"first","affiliation":[{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-2539","authenticated-orcid":false,"given":"Sami","family":"Kilpinen","sequence":"additional","affiliation":[{"name":"Molecular and Integrative Biosciences Research Programme University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-7250","authenticated-orcid":false,"given":"Maria","family":"von Willebrand","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalle","family":"Ojala","sequence":"additional","affiliation":[{"name":"HUS Vatsakeskus Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-3690","authenticated-orcid":false,"given":"Tom","family":"B\u00f6hling","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-4829","authenticated-orcid":false,"given":"Virve","family":"Koljonen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-5509","authenticated-orcid":false,"given":"Harri","family":"Sihto","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00002"},{"issue":"1","key":"e_1_2_12_3_1","article-title":"Malignant Eccrine Porocarcinoma in Finland During 2007 to 2017","volume":"101","author":"Merilainen A. 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