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Using machine learning (LASSO and SVM\u2010RFE) on GSE16134 and GSE173078 datasets,\n                    <jats:italic>CFI<\/jats:italic>\n                    and\n                    <jats:italic>COQ2 were<\/jats:italic>\n                    identified as key genes, with good diagnostic performance (AUC &gt;\u20090.75). GSEA linked these genes to MAPK signalling, endocytosis, and ubiquitin\u2010mediated proteolysis. Immune infiltration analysis revealed higher plasma cells and lower CD8 T cells in periodontitis. Molecular docking identified amiodarone as a potential compound with strong binding affinity to CFI and COQ2. The expression trends of\n                    <jats:italic>CFI<\/jats:italic>\n                    (upregulated) and\n                    <jats:italic>COQ2<\/jats:italic>\n                    (downregulated) were first confirmed in TNF\u2010\u03b1\/IL\u20101\u03b2\u2010stimulated human periodontal ligament cells and further validated in a rat ligature\u2010induced periodontitis model. These findings suggest that\n                    <jats:italic>CFI<\/jats:italic>\n                    and\n                    <jats:italic>COQ2<\/jats:italic>\n                    are potential diagnostic biomarkers and therapeutic targets for periodontitis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71141","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:50:38Z","timestamp":1776484238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Key Genes Involved in Lactic Acid Metabolism in Periodontitis Based on Bioinformatics Analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6286","authenticated-orcid":false,"given":"Bijun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-8218","authenticated-orcid":false,"given":"Leiying","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Endodontics The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520908533"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"issue":"4","key":"e_1_2_11_4_1","article-title":"Treatment of Periodontitis for Glycaemic Control in People With Diabetes Mellitus","volume":"4","author":"Simpson T. 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