{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:17:30Z","timestamp":1778653050305,"version":"3.51.4"},"reference-count":96,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features, expression regulatory mechanism and disease associations. In oncology, it suppresses metastasis via enhancing the stability of certain mRNAs and immunomodulation yet exhibits oncogenic properties in triple\u2010negative breast cancer. Cardiovascular manifestations demonstrate dose\u2010sensitive pathology: deficiency causes arrhythmogenic cytoskeletal disorganization, while overexpression induces \u03b2\u2010tubulin hyper polymerization and ventricular maldevelopment. Epigenetic silencing by miR\u2010484 exacerbates metabolic liver disease, whereas defective interaction with the large\u2010conductance Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010activated K\n                    <jats:sup>+<\/jats:sup>\n                    (BK) channel drives diabetic vasculopathy. Neurologically, it modulates synaptic remodelling and neuroinflammatory pathways. Functioning as a signalling nexus, SORBS2 interconnects chronic inflammation, oxidative stress and metabolic dysfunction, supporting \u2018one target for multiple diseases\u2019 strategy. Future research requires integration of single\u2010cell omics, Artificial intelligence (AI)\u2010based drug design and epigenetic editing for clinical translation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71160","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:45:11Z","timestamp":1777347911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SORBS2<\/scp>\n                    : A Molecular Nexus in Multisystem Diseases Through Scaffold\u2010Mediated Regulation"],"prefix":"10.1111","volume":"30","author":[{"given":"Qiwei","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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