{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:29:52Z","timestamp":1786386592499,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Medically intractable temporal lobe epilepsy is associated with potential neuronal and glial damage in key brain structures, including the hippocampus and amygdala. This study aimed to examine apoptosis, caspase expression, and glial activation markers in these regions, and to evaluate their associations with clinical variables. Hippocampal and amygdala tissues from 17 patients with medically intractable epilepsy and autopsy\u2010derived non\u2010epileptic controls were examined for cellular apoptosis (TUNEL), caspase\u20103, \u20109, and \u201012, as well as GFAP (astrocytic marker) and IBA1 (microglial marker) expression using immunohistochemistry. Correlation analyses were performed to evaluate associations between these molecular markers and various clinical variables. TUNEL\u2010positive cells and caspase\u20103 expression were significantly increased in both the hippocampus and amygdala of patients with medically intractable epilepsy compared to control subjects. Caspase\u20109 and caspase\u201012 were selectively elevated in the amygdala, while GFAP was upregulated in both regions, and IBA1 showed no significant differences. Protein expression patterns varied with age, sex, psychiatric comorbidities, seizure type and frequency, traumatic brain injury, and antiseizure drug treatment. Age at seizure onset, epilepsy duration, and total seizure numbers were associated with distinct molecular profiles. The epileptic hippocampal and amygdala tissues exhibit distinct, region\u2010specific changes in apoptotic and glial markers. These findings suggest that apoptosis and glial alterations may contribute to region\u2010specific pathological mechanisms underlying medically intractable temporal lobe epilepsy and may be influenced by clinical disease characteristics.<\/jats:p>","DOI":"10.1111\/jcmm.71179","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:39:51Z","timestamp":1778816391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apoptosis and Glial Marker Profiles in Hippocampus and Amygdala of Medically Intractable Temporal Lobe Epilepsy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-0390","authenticated-orcid":false,"given":"Fatemeh","family":"Alipour","sequence":"first","affiliation":[{"name":"Shefa Neuroscience Research Center Khatam Alanbia Hospital  Tehran 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