{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:54:13Z","timestamp":1781535253878,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C2093566"],"award-info":[{"award-number":["2021R1A2C2093566"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000212496"],"award-info":[{"award-number":["RS\u20102023\u201000212496"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Insulin substantially promotes the growth of malignant cells that overexpress the insulin receptor (INSR), and insulin excess has been recognised as a cancer\u2010promoting factor in patients. Interferon\u2010induced transmembrane protein 1 (IFITM1) is also overexpressed in various cancers. In this study, we investigate the association between insulin signalling\u2010induced IFITM1 expression and multiple myeloma (MM) aggressiveness. We observed that expression of both INSR and IFITM1 was significantly elevated in symptomatic MM patients compared with those with monoclonal gammopathy of undetermined significance (MGUS) and smouldering MM (SMM). Notably, IFITM1\u2014but not INSR\u2014expression correlated with prognosis following autologous stem cell transplantation and bortezomib\u2010based induction therapy. Further analysis revealed that IFITM1 expression in bone marrow plasma cells was associated with the concentrations of insulin and insulin\u2010like growth factor 2 (IGF\u2010II) in the bone marrow microenvironment. Insulin and IGF\u2010II enhanced MM cell proliferation through IFITM1 upregulation, whereas suppression of IFITM1 abrogated the proliferative effects of these ligands. Moreover, insulin and IGF\u2010II attenuated apoptosis and the inhibition of cell migration induced by the proteasome inhibitors (PIs) bortezomib and carfilzomib, and these effects were reversed by IFITM1 knockdown. The ability of insulin to reduce bortezomib\u2010induced apoptosis and G2\/M phase cell cycle arrest was likewise dependent on IFITM1 expression. Collectively, these findings suggest that insulin\u2010induced IFITM1 plays a pivotal role in MM progression and resistance to bortezomib, highlighting IFITM1 as a potential prognostic biomarker and therapeutic target.<\/jats:p>","DOI":"10.1111\/jcmm.71183","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:07:42Z","timestamp":1781327262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insulin Signalling\u2010Inducible\n                    <scp>IFITM1<\/scp>\n                    Promotes Multiple Myeloma Progression and Bortezomib Resistance"],"prefix":"10.1111","volume":"30","author":[{"given":"Ji\u2010Young","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeojin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-0392","authenticated-orcid":false,"given":"Chang\u2010Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14304"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010018\u20100206\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10849"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12233"},{"key":"e_1_2_10_6_1","volume-title":"The Insulin Receptor and Its Signal Transduction Network","author":"De Meyts P."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010016\u20100508\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017\u201000073"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113615"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011\u20100231"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403997"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.192"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.9.2841"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.40.23860"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144934"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2010_02_123"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101438.2007.01169.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.034"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.04.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977\u2010017\u20100377\u2010y"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010014\u20102216\u20108"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/414799a"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"683","article-title":"Insulin and Cancer (Review)","volume":"18","author":"Argil\u00e9s J. 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