{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:04:49Z","timestamp":1784088289229,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010566","name":"Rome Foundation","doi-asserted-by":"publisher","award":["Prot.317A\/I"],"award-info":[{"award-number":["Prot.317A\/I"]}],"id":[{"id":"10.13039\/100010566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    SARS\u2010CoV\u20102 has caused a global pandemic, resulting in over two million deaths and creating an urgent need for effective treatments. Severe COVID\u201019 is frequently complicated by respiratory failure and acute respiratory distress syndrome (ARDS), the primary drivers of mortality. Indole\u20103\u2010Carbinol (I3C), a natural compound derived from\n                    <jats:italic>Brassicaceae<\/jats:italic>\n                    that acts as an inhibitor of HECT family E3 ubiquitin ligases, exhibits potent anti\u2010SARS\u2010CoV\u20102 activity and inhibits viral egress. However, its in\u00a0vivo therapeutic efficacy against SARS\u2010CoV\u20102\u2010induced lung injury remains unproven. We evaluated the therapeutic efficacy of I3C in reducing the severity of SARS\u2010CoV\u20102 infection and associated lung lesions using the Syrian golden hamster (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mesocricetus auratus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) model, which recapitulates the acute lung injury observed in human COVID\u201019. Treatment with a non\u2010toxic dose of I3C (2\u2009mg) significantly ameliorated disease across all parameters, reducing weight loss, improving clinical symptom scores and\n                    <jats:italic>reducing histopathological lung damage observed post\u2010mortem<\/jats:italic>\n                    . A significant reduction in pulmonary TNF\u2010\u03b1 levels accompanied this. These findings indicate that I3C mitigates COVID\u201019\u2010related morbidity at clinically relevant, non\u2010toxic doses. Given its dual antiviral and anti\u2010inflammatory mechanisms, I3C represents a compelling therapeutic candidate for further clinical investigation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71213","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:50:11Z","timestamp":1783929011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Efficacy of Indole\u20103\u2010Carbinol Against\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102\u2010Induced Acute Respiratory Distress Syndrome: A Dual Antiviral and Anti\u2010Inflammatory Approach in a Golden Syrian Hamster Model"],"prefix":"10.1111","volume":"30","author":[{"given":"Centofanti","family":"Federica","sequence":"first","affiliation":[{"name":"Department of Biomedicine and Prevention Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizzacasa","family":"Barbara","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latini","family":"Andrea","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention Tor Vergata University of Rome  Rome Italy"},{"name":"UniCamillus Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biancolella","family":"Michela","sequence":"additional","affiliation":[{"name":"Department of Biology Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pocci","family":"Marco","sequence":"additional","affiliation":[{"name":"Anatomy and Pathological Histology Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servadei","family":"Francesca","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, and Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-1309","authenticated-orcid":false,"given":"Scimeca","family":"Manuel","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, and Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauriello","family":"Alessandro","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, and Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Palyi","sequence":"additional","affiliation":[{"name":"National Center for Public Health and Pharmacy National Biosafety Laboratory  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Deri","sequence":"additional","affiliation":[{"name":"National Center for Public Health and Pharmacy National Biosafety Laboratory  Budapest Hungary"},{"name":"European Research Infrastructure on Highly Pathogenic Agents, ERINHA AISBL  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenike","family":"Novak","sequence":"additional","affiliation":[{"name":"National Center for Public Health and Pharmacy National Biosafety Laboratory  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Kis","sequence":"additional","affiliation":[{"name":"National Center for Public Health and Pharmacy National Biosafety Laboratory  Budapest Hungary"},{"name":"European Research Infrastructure on Highly Pathogenic Agents, ERINHA AISBL  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Filippone","sequence":"additional","affiliation":[{"name":"European Research Infrastructure on Highly Pathogenic Agents, ERINHA AISBL  Brussels Belgium"},{"name":"ERINHA Central Coordinating Unit  Paris cedex 13 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Paolo","family":"Pandolfi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-602X","authenticated-orcid":false,"given":"Novelli","family":"Giuseppe","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization(WHO). 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