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Trained rats were submitted to 8\u2010weeks of endurance treadmill training with chronic mild stress (CMS), TS rats, and without CMS (T). Non\u2010trained rats (NTS and NT groups) were submitted to identical procedures except for training. NTS and TS groups were submitted to a CMS protocol for 3\u2009weeks. Elevated corticosterone levels indicate an initial triggering factor that mediates the downstream intracellular signalling networks related to the MMPs and RAS activation after CMS. Endurance training confers cardioprotection against the stress response by lowering the Ang 3\u20137 levels, whereas increased activity of MMPs was observed in TS rats. Chronic stress disrupts the cardiac function, MMPs, and RAS activation by increasing the cardiac activity of the MMP\u20102 activity and Ang 1\u20139 levels with concomitant reduction of cardiac and blood levels of Ang 1\u20137. 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Aerobic endurance training is a potential exercise\u2010based strategy that counteracts the stress\u2010related disturbances in the MMPs and RAS signalling pathways.<\/jats:p>","DOI":"10.1111\/jcmm.71218","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:52:56Z","timestamp":1786629176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aerobic Endurance Training Modulates Cardiac Renin\u2010Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5952","authenticated-orcid":false,"given":"Vinicius","family":"Guzzoni","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine Federal University of S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana 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