{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:54:09Z","timestamp":1781535249408,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    During the development of periodontitis, osteoclast function is activated by the MAPK pathway. MMPs are able to participate in cross\u2010activation and self\u2010activation cascades, thereby modulating gene expression for osteoclast differentiation. Among the MAPK family, the p38 family has a particularly significant impact on the development of chronic inflammation in periodontal tissue. Activation of p38 MAPK signalling directly or indirectly mediates the expression of inflammatory cytokines, thereby synergistically stimulating MMP production. This experiment aims to understand how p38 MAPK affects inflammatory hPDLFs treated with Pseudomonas gingivalis. Compared with the control group, secretion of MMP\u20102, \u22121, and \u22123 of hPDLFs treated with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010LPS was significantly increased and was closely related to the concentration of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010LPS. Cell scratching and CCK\u20108 experiments revealed that MMP\u20101, \u22122, and \u22123 inhibited cell proliferation and motility. To explore the signalling pathways involved in p38 MAPK regulation, hPDLFs were treated with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010LPS alone or in combination with a p38 MAPK kinase inhibitor. The results suggest that MMP\u20101, \u22122, and \u22123 can serve as salivary biomarkers for the chronic inflammatory disease periodontitis and regulate inflammation through the p38 MAP kinase pathway.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71223","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:12:54Z","timestamp":1780373574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of P38\n                    <scp>MAPK<\/scp>\n                    Pathway Inhibition on the Metabolism of Periodontal Ligament Fibroblasts During Inflammation"],"prefix":"10.1111","volume":"30","author":[{"given":"Cheng","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Stomatology Shaoxing Central Hospital  Zhejiang 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