{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:54:11Z","timestamp":1781535251317,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160098"],"award-info":[{"award-number":["82160098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2024JJA141030"],"award-info":[{"award-number":["2024JJA141030"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lipid deposition and foam cell formation drive atherogenesis. Lipid uptake regulator 1 (LUR1) and N6\u2010methyladenosine (m6A) modification play key roles in systemic lipid homeostasis. Bioinformatic analyses revealed a negative correlation between fat mass and obesity\u2010associated protein (FTO) and LUR1 expression and abundant m6A sites within the LUR1 mRNA strand. We therefore hypothesized that FTO\u2010catalysed demethylation modulates LUR1 expression and lipid accumulation in macrophages, thereby influencing aortic plaque development. Acetylated low\u2010density lipoprotein\u2010loaded THP\u20101 macrophages were transduced with recombinant lentiviruses, and FTO and LUR1 expression was determined by Western blotting and qPCR. m6A abundance was measured by methylated RNA immunoprecipitation\u2013qPCR. Intracellular lipids were quantified by ELISA, and lipid droplets (LDs) were quantified using Oil Red O (ORO) staining. The plasma lipid concentration, aortic sinus plaque area and lipid deposition were evaluated by biochemical assays and histological staining in high\u2010fat\u2010fed apoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice that received recombinant adeno\u2010associated viruses. The results revealed that elevated FTO expression not only reduced LUR1 expression and its m6A modification and decreased intracellular LD and cholesterol ester contents but also significantly decreased plasma triglyceride (TG) and low\u2010density lipoprotein\u2010cholesterol levels (LDL\u2010C) and decreased the aortic lesion area. Co\u2010overexpression of FTO and LUR1 abolished these protective effects. These findings indicate that FTO\u2010erased m6A modification decreases LUR1 expression in macrophages to inhibit intracellular lipid accumulation and the occurrence of atherosclerosis (AS).\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71234","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:02:52Z","timestamp":1781236972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>FTO<\/scp>\n                    \u2010Catalysed Demethylation of\n                    <scp>LUR1 mRNA<\/scp>\n                    Suppresses Macrophage Lipid Accumulation and Aortic Atherosclerosis"],"prefix":"10.1111","volume":"30","author":[{"given":"Xiang\u2010Yang","family":"Tang","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Diabetic Systems Medicine &amp; Cardiology Department of the Second Affiliated Hospital Guilin Medical University  Guilin Guangxi 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University  Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Diabetic Systems Medicine &amp; Cardiology Department of the Second Affiliated Hospital Guilin Medical University  Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-194X","authenticated-orcid":false,"given":"Yun\u2010Cheng","family":"Lv","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Diabetic Systems Medicine &amp; Cardiology Department of the Second Affiliated Hospital Guilin Medical University  Guilin Guangxi 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