{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:59:18Z","timestamp":1785301158466,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870177"],"award-info":[{"award-number":["81870177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["No. 2018JP002"],"award-info":[{"award-number":["No. 2018JP002"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cardiac glucose metabolism is critically involved in the pathophysiology of myocardial infarction. This study investigated whether Qiliqiangxin (\n                    <jats:italic>QL<\/jats:italic>\n                    ), a traditional Chinese medicine, improves myocardial glucose uptake and aerobic oxidation after myocardial infarction (MI) and explored the underlying mechanisms.\n                    <jats:italic>QL<\/jats:italic>\n                    treatment significantly increased LVEF, enhanced myocardial glucose uptake, reduced fibrosis, apoptosis, ROS production and elevated ATP generation along with activity of pyruvate dehydrogenase (PDH) and citrate synthase (CS). These effects were abolished by HIF\u20101\u03b1\u2010shRNA transduction.\n                    <jats:italic>QL<\/jats:italic>\n                    also upregulated the expression of HIF\u20101\u03b1, MIF, p\u2010AMPK\u03b1, GLUT\u20104, hexokinase 2 (HK2), PDH and CS, which were similarly attenuated by HIF\u20101\u03b1 knockdown. In conclusion, our study demonstrated that\n                    <jats:italic>QL<\/jats:italic>\n                    enhances myocardial glucose uptake and aerobic oxidation in a murine model of post\u2010MI heart failure. Genetic inhibition of HIF\u20101\u03b1 reverses these beneficial effects, suggesting the involvement of the HIF\u20101\u03b1\/MIF\/AMPK signalling axis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71238","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:20:27Z","timestamp":1784550027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Qiliqiangxin Improves Cardiac Glucose Metabolism After Myocardial Infarction Through a\n                    <scp>HIF<\/scp>\n                    \u20101\u03b1\/\n                    <scp>MIF<\/scp>\n                    \/\n                    <scp>AMPK<\/scp>\n                    Axis"],"prefix":"10.1111","volume":"30","author":[{"given":"Zimu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2847-3828","authenticated-orcid":false,"given":"Hanqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Xuzhou Center Hospital  Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-5787","authenticated-orcid":false,"given":"Chaofu","family":"Li","sequence":"additional","affiliation":[{"name":"Bioengineering College of Chongqing University Chongqing University Central Hospital (Chongqing Emergency Medical Center)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya'nan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"},{"name":"Department of Cardiology Shanghai Geriatric Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60107-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.05.063"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487871"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000230"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13572"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.04.14"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13111"},{"issue":"6","key":"e_1_2_12_11_1","first-page":"6596","article-title":"Qiliqiangxin Improves Cardiac Function and Attenuates Cardiac Remodeling in Rats With Experimental Myocardial Infarction","volume":"8","author":"Wang J.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.13"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000226"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1283150"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.12.040"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02251-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-11-66"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu071"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.01.005"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040862"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494869"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11635"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.08.152"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:06:27Z","timestamp":1785297987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jcmm.71238"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71238","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71238"}}