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Calebin\u2010A, a bioactive compound derived from\n                    <jats:italic>Curcuma<\/jats:italic>\n                    species, has shown promise in managing obesity and its complications. This study utilized bioinformatics tools to explore the molecular mechanisms of Calebin\u2010A in obesity. Transcriptomic data from obese and normal omental adipose tissue (GSE286454) were analysed, identifying 317 differentially expressed genes (DEGs). Functional enrichment analysis indicated a notable engagement of lysosomal activity, immune response, cell migration, axon guidance and apoptosis pathways. A STRING\u2010based protein\u2013protein interaction network revealed nine hub genes through a composite centrality score. Among these, CTSB, CTSZ, CTSA, GRN and TUBB exhibited upregulation and were prioritized for subsequent analysis. External validation (GSE59034; 16 obese vs. 16 controls) corroborated the consistent upregulation of CTSB, CTSZ, GRN and CTSA. Target prediction analysis identified 443 potential targets for Calebin\u2010A, with pathway\u2010level overlap suggesting a convergence on immune, lysosomal and cytoskeletal processes. Molecular docking studies indicated favourable binding affinities (\u22125.2 to \u22127.1\u2009kcal\/mol), with CTSZ demonstrating the most robust interaction. A 100\u2009ns molecular dynamics simulation validated structural stability and indicated favourable binding free energy (MM\u2010PBSA \u0394\n                    <jats:italic>G<\/jats:italic>\n                    \u2009\u2248\u2009\u2212110\u2009kJ\/mol). Results suggest that Calebin\u2010A targets genes and proteins involved in energy balance and inflammation, offering insights into its anti\u2010obesity potential. These findings provide a foundation for experimental validation and therapeutic development.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71244","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:58:42Z","timestamp":1781323122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Potential of Calebin\u2010A in Targeting Obesity\u2010Related Genes and Pathways"],"prefix":"10.1111","volume":"30","author":[{"given":"Ali","family":"Mahmoudi","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine Abadan University of Medical Sciences  Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Saeedi\u2010Boroujeni","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine Abadan University of Medical Sciences  Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sercan","family":"Karav","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-769X","authenticated-orcid":false,"given":"Prashant","family":"Kesharwani","sequence":"additional","affiliation":[{"name":"Next\u2010Generation Translational Nanomedicine Laboratory, Department of Pharmaceutical Sciences Dr. Harisingh Gour Vishwavidyalaya  Sagar Madhya Pradesh India"},{"name":"University Institute of Pharma Sciences, Chandigarh University  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Centre for Research Impact and Outcome, Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"},{"name":"Center for Innovation and Inclusive Research Sharda University  Greater Noida Uttar Pradesh India"},{"name":"Applied Biomedical Research Center, Basic Sciences Research Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191707"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.01.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-090419-102644"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60525-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcx152"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177850"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy084"},{"key":"e_1_2_10_9_1","unstructured":"I. 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