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This study investigated whether ellagic acid (EA), a natural antioxidant, attenuates post\u2010MI cardiac fibrosis in ovariectomized rats by reducing oxidative stress and pro\u2010inflammatory mediators. MI was induced by coronary artery ligation, and EA (30\u2009mg\/kg) was administered orally for 4\u2009weeks. Hemodynamic parameters, collagen deposition, infarct size, matrix metalloproteinase\u20108 (MMP\u20108), NO, superoxide anion and inflammatory cytokines were assessed. MI resulted in ventricular dysfunction, increased collagen deposition and elevated levels of MMP\u20108, interleukin\u20106 (IL\u20106) and superoxide anion. EA treatment improved hemodynamic function, reduced collagen deposition, decreased MMP\u20108, IL\u20106 and superoxide anion, and enhanced NO bioavailability. These findings demonstrate that EA mitigates cardiac fibrosis and ventricular dysfunction through antioxidant and anti\u2010inflammatory mechanisms, highlighting its potential as a cardioprotective compound in post\u2010MI conditions under oestrogen deficiency.<\/jats:p>","DOI":"10.1111\/jcmm.71262","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:14:21Z","timestamp":1782533661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ellagic Acid Attenuates Oxidative Stress and Improves Cardiovascular Function Following Myocardial Infarction in Ovariectomized Rats"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-8354","authenticated-orcid":false,"given":"La\u00eds Lopes","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center Federal University of Esp\u00edrito Santo  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-1642","authenticated-orcid":false,"given":"Ildernandes Vieira","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center Federal University of Esp\u00edrito Santo  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2992-9221","authenticated-orcid":false,"given":"Erika Ferreira","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center Federal University of Esp\u00edrito Santo  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4998-2259","authenticated-orcid":false,"given":"Deiviany Santana Santos","family":"Lima","sequence":"additional","affiliation":[{"name":"Mucuri School of Medicine, Graduate Program in Health Sciences Federal University of Jequitinhonha and Mucuri Valleys  Te\u00f3filo Otoni Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-9325","authenticated-orcid":false,"given":"Virginia Soares","family":"Lemos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-2248","authenticated-orcid":false,"given":"A. 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