{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:05:30Z","timestamp":1791515130150,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD"],"award-info":[{"award-number":["PAPD"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Wear debris surrounding implants plays a crucial role in the development of periprosthetic osteolysis (PPO) by inducing the aggregation of osteoclasts around the prosthesis. Oxypaeoniflorin (OPF), a derivative of Paeoniflorin, is primarily sourced from the root of the traditional Chinese medicine peony and possesses anti\u2010inflammatory and antioxidant properties. Currently, the effects of OPF on osteoclast activation and particle\u2010induced bone resorption remain unclear. In this study, we examined the regulatory effect of OPF on titanium particle\u2010induced bone erosion in\u00a0vivo and utilized bone marrow macrophages to investigate the impact of OPF on osteoclast differentiation and resorptive function along with its potential mechanisms. Our results indicate that in\u00a0vitro, OPF inhibits RANKL\u2010induced osteoclastogenesis, osteoclast\u2010dependent resorption, and the expression of osteoclast marker genes through the activation of Nrf2\u2010mediated oxidative stress signalling. Furthermore, in\u00a0vivo, OPF suppressed titanium particle\u2010induced bone loss and osteoclast formation. Our data further confirm the protective effect of OPF against titanium particle\u2010induced osteolysis from a novel perspective of preventing bone erosion, establishing OPF as a suitable drug for the prevention of PPO.<\/jats:p>","DOI":"10.1111\/jcmm.71266","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:57:34Z","timestamp":1782997054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxypaeoniflorin Ameliorates Titanium Particle\u2010Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts"],"prefix":"10.1111","volume":"30","author":[{"given":"Feng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Hei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Chuzhou Hospital Affiliated With Anhui Medical University  Chuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"},{"name":"Department of Orthopedics Surgery The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital  Suzhou Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"},{"name":"Department of Orthopedics Hai'an People's Hospital  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-2803","authenticated-orcid":false,"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-4884","authenticated-orcid":false,"given":"Yaozeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University; Orthopedic Institute, Medical College, Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Hai'an People's Hospital  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.09.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-020-03611-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02610-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-013-0192-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15376"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-02452-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122091"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.042"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.09.034"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.046"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200310151-00006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111758"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-21-10"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401285"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116538"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1596491"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194925"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03713.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2022.vol36.0084"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.49.69"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115253"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04238-x"},{"issue":"2","key":"e_1_2_11_25_1","first-page":"239","article-title":"Oxypaeoniflorin Improves Myocardial Ischemia\/Reperfusion Injury by Activating the Sirt1\/Foxo1 Signaling Pathway","volume":"67","author":"Wang K.","year":"2020","journal-title":"Acta Biochimica Polonica"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-45909-3"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2048432"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03784-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.641162"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-006-0524-0"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186629"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4282"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.60.101"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1350649"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf304768p"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00905-X"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193420917582"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2021.11.009"},{"issue":"2","key":"e_1_2_11_39_1","first-page":"99","article-title":"Wear Particles","volume":"88","author":"Jacobs J. J.","year":"2006","journal-title":"Journal of Bone and Joint Surgery. American Volume"},{"issue":"3","key":"e_1_2_11_40_1","first-page":"206","article-title":"Wear Debris in Metal\u2010On\u2010Metal Bearings and Modular Junctions: What Have We Learned From the Last Decades?","volume":"52","author":"Knecht C.","year":"2023","journal-title":"Orthopadie (Heidelberg)"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302202"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2012.10.006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2001.28719"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e31804b4147"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2017.10.070"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110505"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6878026"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12907"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111032"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.40.2248"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa098"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020320"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12122094"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101309"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17692"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01413-w"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34486"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-015-3021-2"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1887-4"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:15:05Z","timestamp":1784085305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":58,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jcmm.71266"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71266","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71266"}}