{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:04:57Z","timestamp":1784088297482,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82300931"],"award-info":[{"award-number":["NSFC 82300931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myeloid\u2010derived growth factor (MYDGF) offers new insights into inflammation and endothelial function, yet its role in endothelial progenitor cells (EPCs) and diabetes\u2010related hindlimb ischemia (DLI) remains unclear. In this study, we found that MYDGF depletion impaired the angiogenic function of EPCs, leading to reduced vascularisation and decreased blood flow in diabetic mice with hindlimb ischemia. Conversely, treatment with adeno\u2010associated virus\u2013mediated MYDGF restored vascularisation and improved blood perfusion. In\u00a0vitro, treatment with recombinant MYDGF attenuated EPC dysfunction, apoptosis and inflammatory responses. Mechanistic studies revealed that these protective effects were mediated via the AKT\/HIF\u20101\u03b1 pathway, and silencing HIF\u20101\u03b1 abrogated the benefits of MYDGF both in\u00a0vivo and in\u00a0vitro. Together, these findings identified MYDGF as a potential therapeutic target for DLI.<\/jats:p>","DOI":"10.1111\/jcmm.71287","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:39:58Z","timestamp":1784032798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid\u2010Derived Growth Factor Improves Endothelial Progenitor Cell Function and Angiogenesis in Mice With Diabetic Hindlimb Ischemia by Activating Akt\/HIF\u20101\u03b1 Signalling Pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Wen","family":"Mei","sequence":"first","affiliation":[{"name":"Department of Endocrinology, School of Medicine the Sixth Affiliated Hospital of South China University of Technology (Nanhai District People's Hospital of Foshan)  Foshan 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