{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:16:24Z","timestamp":1788243384972,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chromatin remodelling SWI\/SNF complexes are recurrently altered in malignancies, and some members were found to be associated with immune checkpoint blockade (ICB) response. However, it is unclear whether SWI\/SNF complex genes as a collective factor have clinical relevance. Through pan\u2010cancer analysis of 8507 tumours across 26 types from The Cancer Genome Atlas, we demonstrate that SWI\/SNF loss\u2010of\u2010function (LOF) mutations correlate with elevated immunogenicity markers, such as higher tumour mutational burden (TMB), neoantigen load, and microsatellite instability. SWI\/SNF\u2010LOF tumours exhibited enriched CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell and M1\u2010like macrophage infiltration, upregulation of major histocompatibility complex class genes, and increased expression of immunostimulators, immunoinhibitors, and chemokines. Crucially, in ICB\u2010treated patients across discovery (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009750) and validation (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009562) cohorts encompassing nine cancer types, SWI\/SNF\u2010LOF status consistently predicted superior clinical outcomes, including prolonged overall survival, progression\u2010free survival, and higher objective response rates compared to non\u2010mutated tumours. Multivariate analysis confirmed SWI\/SNF\u2010LOF as an independent ICB response predictor independent of TMB, age, sex, or cancer type. These findings identify SWI\/SNF LOF mutations as promising biomarkers of an inflamed tumour microenvironment and favourable responses to ICB across multiple solid tumours.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71290","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:43:23Z","timestamp":1787719403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss\u2010of\u2010Function Mutations in\n                    <scp>SWI<\/scp>\n                    \/\n                    <scp>SNF<\/scp>\n                    Complexes Associated With Active Tumour Immune Microenvironment Clinical Response to Immune Checkpoint Blockade"],"prefix":"10.1111","volume":"30","author":[{"given":"Zheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology The Seventh Affiliated Hospital of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Affiliated Hospital of Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renji","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The First Affiliated Hospital of University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Data Science Burning Rock Biotech  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Data Science Burning Rock Biotech  Guangzhou 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