{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:26:24Z","timestamp":1786778784593,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To investigate the role of histone deacetylase 2 (HDAC2) in cisplatin resistance in ovarian cancer (OC). Cisplatin\u2010resistant OC cell lines were employed to construct HDAC2 overexpression and knockdown models, and their effects on cell proliferation and apoptosis were examined. Chromatin immunoprecipitation, immunoprecipitation, and dual\u2010luciferase reporter assays were performed to investigate the regulation of SMAD7 protein stability and promoter activity by HDAC2. Expression of DNA damage repair\u2010related genes was detected by qRT\u2010PCR. A xenograft mouse model was established for in\u00a0vivo validation. HDAC2 was highly expressed in cisplatin\u2010resistant OC cells. Overexpression of HDAC2 enhanced drug resistance and inhibited apoptosis and DNA damage, whereas knockdown of HDAC2 exhibited the opposite effects. Mechanistically, HDAC2 directly deacetylated the SMAD7 protein to prevent its degradation rather than suppressing its transcription via H3K27 deacetylation. The HDAC2\/SMAD7 axis promoted drug resistance by activating the Wnt\/\u03b2\u2010catenin signalling pathway and modulating DNA damage repair\u2010related genes. In\u00a0vivo experiments confirmed that HDAC2 knockdown significantly inhibited tumour growth and enhanced the sensitivity. HDAC2 enhances cisplatin resistance in OC by deacetylating and stabilising SMAD7 protein, thereby activating the Wnt\/\u03b2\u2010catenin signalling pathway and promoting DNA damage repair.<\/jats:p>","DOI":"10.1111\/jcmm.71300","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:25:13Z","timestamp":1785817513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HDAC2<\/scp>\n                    \u2010Mediated\n                    <scp>SMAD7<\/scp>\n                    Stabilisation Activates Wnt\/\u03b2\u2010Catenin Signalling to Drive\n                    <scp>DNA<\/scp>\n                    Damage Repair and Cisplatin Resistance in Ovarian Cancer"],"prefix":"10.1111","volume":"30","author":[{"given":"Yingying","family":"He","sequence":"first","affiliation":[{"name":"Department of Pathology Quzhou People's Hospital, The Quzhou Affiliated Hospital, Wenzhou Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Quzhou People's Hospital, The Quzhou Affiliated Hospital, Wenzhou Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Quzhou People's Hospital, The Quzhou Affiliated Hospital, Wenzhou Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Quzhou People's Hospital, The Quzhou Affiliated Hospital, Wenzhou Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1582-8114","authenticated-orcid":false,"given":"Kening","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Quzhou People's Hospital, The Quzhou Affiliated Hospital, Wenzhou Medical University  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.9495"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102295"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-081313-121208"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-01967-3"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026831"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.03.016"},{"issue":"5","key":"e_1_2_13_8_1","first-page":"1213","article-title":"HDAC2 Overexpression Correlates With Aggressive Clinicopathological Features and DNA\u2010Damage Response Pathway of Breast Cancer","volume":"7","author":"Shan W.","year":"2017","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413121"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141223774"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503134200"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00351.2022"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2016-0307"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.09.040"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2019.10.007"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/17501911.2025.2460900"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2203-7"},{"issue":"2","key":"e_1_2_13_18_1","first-page":"375","article-title":"De\u2010Repression of the p21 Promoter in Prostate Cancer Cells by an Isothiocyanate via Inhibition of HDACs and c\u2010Myc","volume":"33","author":"Wang L. 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