{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:16:17Z","timestamp":1788243377368,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This systematic review aimed to: (1) identify the splicing variants of\n                    <jats:italic>IL23R<\/jats:italic>\n                    and\n                    <jats:italic>IL17RA<\/jats:italic>\n                    reported in the literature; (2) perform a multiple alignment analysis to describe the isoforms of IL\u201023R and IL\u201017RA; and (3) compare the expression levels of IL\u201023R, IL\u201017RA, and their soluble isoforms (sIL\u201023R and sIL\u201017RA) in patients with periodontitis and periodontally healthy individuals. The study protocol followed PRISMA guidelines and was registered in PROSPERO (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251267367\">CRD420251267367<\/jats:ext-link>\n                    ). Six databases (PubMed, ScienceDirect, Scopus, Web of Science, EBSCO, and Google Scholar) were searched without restrictions on year or language. The descriptors used were: \u2018Interleukin\u201023 Receptor,\u2019 \u2018IL\u201023R,\u2019 \u2018Interleukin\u201017 Receptor A\u2019 \u2018IL\u201017RA,\u2019 \u2018Alternative Splicing,\u2019 \u2018Splice Variants,\u2019 \u2018Isoforms,\u2019 and \u2018Periodontitis.\u2019 The bioinformatics analysis was performed using CLUSTALW (V.1.83), InterPro and DeepTMHMM. Risk of bias was assessed with the QUIN and JBI tools for cross\u2010sectional studies. Of 104 articles, four in\u00a0vitro studies and eight cross\u2010sectional studies were included. Qualitative analysis revealed that to date there are 32 splicing variants of the\n                    <jats:italic>IL23R<\/jats:italic>\n                    gene, while only one splicing variant has been reported for\n                    <jats:italic>IL17RA<\/jats:italic>\n                    . CLUSTALW, InterPro and DeepTMHMM analysis showed that these splicing variants result in 23 isoforms which can be soluble forms, complete intracellular peptides, truncated extracellular or intracellular peptides, or complete structures with truncated extracellular and\/or intracellular domains. All studies had a low risk of bias. IL\u201023R and IL\u201017RA exhibit structural diversity resulting from alternative splicing, with IL\u201023R demonstrating significantly greater isoform complexity. However, the biological significance of these isoforms in periodontitis remains unclear and requires further investigation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71325","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:10:44Z","timestamp":1787029844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u201023 Receptor and Interleukin\u201017 Receptor A: Splice Variants, Isoforms and Their Relationship With Periodontitis\u2014A Systematic Review and Bioinformatic Analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7969","authenticated-orcid":false,"given":"Mario Alberto","family":"Alarc\u00f3n\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Molecular Biology in Medicine Program, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"},{"name":"Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-8810","authenticated-orcid":false,"given":"Celia","family":"Guerrero\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-2514","authenticated-orcid":false,"given":"Daniel","family":"Ortu\u00f1o\u2010Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuroimmunobiology, Institute of Translational Neurosciences, Department of Molecular Biology and Genomics, University Center for Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-1387","authenticated-orcid":false,"given":"Sarah Monserrat","family":"Lomel\u00ed\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center University of Guadalajara (CUCIENEGA\u2010UdeG)  Ocotl\u00e1n Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9321-0095","authenticated-orcid":false,"given":"Julieta Sarai","family":"Becerra\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Clinics, Los Altos University Center University of Guadalajara (CUALTOS\u2010UdeG)  Tepatitl\u00e1n de Morelos Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-0551","authenticated-orcid":false,"given":"Javier","family":"Flores\u2010Fraile","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University  Chennai India"},{"name":"Department of Prosthodontics, Faculty of Stomatology Yerevan State Medical University after Mkhitar Heratsi  Yerevan Armenia"},{"name":"Department of Prosthodontics, School of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1998.tb02419.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12447"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13769"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph22040624"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1533658"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143394"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1435054"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1578635"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004077\u20100"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.021"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2025.259061"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251\u2010005\u20100067\u20100"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.51"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.64"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.09.012"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2017.53.5.2613690"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1230"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13030401"},{"key":"e_1_2_14_22_1","unstructured":"www.genome.jp\/tools\u2010bin\/clustalw."},{"key":"e_1_2_14_23_1","unstructured":"www.ncbi.nlm.nih.gov\/genbank\/."},{"key":"e_1_2_14_24_1","unstructured":"www.uniprot.org."},{"key":"e_1_2_14_25_1","unstructured":"www.ebi.ac.uk\/interpro\/."},{"key":"e_1_2_14_26_1","unstructured":"www.dtu.biolib.com\/DeepTMHMM."},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2022.05.019"},{"key":"e_1_2_14_28_1","volume-title":"Joanna Briggs Institute Reviewer's Manual","author":"Moola S.","year":"2017"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509339889"},{"issue":"2","key":"e_1_2_14_30_1","first-page":"46","article-title":"Determinaci\u00f3n De La Concentraci\u00f3n De IL\u201023 y el Receptor Soluble a IL\u201017 (IL\u201017RA) En Suero y Plasma De Pacientes Con Periodontitis Cr\u00f3nica y Agresiva","author":"Pe\u00f1a\u2010Echeverr\u00eda P. A.","year":"2016","journal-title":"Revista Mexicana de Periodontolog\u00eda"},{"issue":"1","key":"e_1_2_14_31_1","first-page":"5","article-title":"Determinaci\u00f3n De Los Niveles Del Receptor Soluble De IL\u201023 En Suero y Plasma De Pacientes Con Periodontitis Cr\u00f3nica y Agresiva","author":"Rivadeneyra\u2010Burgos C.","year":"2016","journal-title":"Revista Mexicana de Periodontolog\u00eda"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2005380269"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23963"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12168051"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1569490"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/ijod\/8893504"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.018"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2586"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.715870"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.710541"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010019\u20100514\u2010y"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2025.01.002"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:00:19Z","timestamp":1788242419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jcmm.71325"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71325","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71325"}}