{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:16:23Z","timestamp":1788243383364,"version":"build-2803163510"},"reference-count":90,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emetine (EMT), a naturally occurring tetrahydroisoquinoline alkaloid, shows diverse biological actions, including anticancer effects. Despite existing studies, the role of EMT derivatives in cancer, particularly in relation to the PI3K\/AKT\/mTOR signalling pathway, remains largely underexplored. This review explores the potential of EMT in targeting PI3K\/AKT\/mTOR molecular pathways across different cancer types. Data were collected from reliable and well\u2010established sources, including PubMed, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. Findings showed that EMT derivatives suppress PI3K\u2010AKT\u2010mTOR pathway activity in multiple cancers such as liver, gastric,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acute-myeloid-leukemia\">acute myeloid leukaemia<\/jats:ext-link>\n                    (AML), and brain, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 0.0244 to 1\u2009\u03bcM. Beyond its anticancer activity, EMT showed broad pharmacological relevance, including antiviral, antiparasitic, and contraceptive activities. Preclinical assessments suggest preferential cytotoxicity toward cancer cells at low concentrations; however, known dose\u2010dependent adverse effects, including cardiotoxicity and emetic responses at higher doses, necessitate careful dose optimization before clinical translation. Clinical evidence remains insufficient, and EMT should be considered a preclinically active compound warranting further rigorous translational investigation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71328","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:54:50Z","timestamp":1787547290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emetine and Its Derivatives as Anticancer Agents Targeting the\n                    <scp>PI3K<\/scp>\n                    \/\n                    <scp>AKT<\/scp>\n                    \/\n                    <scp>mTOR<\/scp>\n                    Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights"],"prefix":"10.1111","volume":"30","author":[{"given":"Mst. Ismatara","family":"Khatun","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science and Technology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-8586","authenticated-orcid":false,"given":"Samy","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif Hassan","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Chemistry York College of The City University of New York (CUNY)  Jamaica New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7560-4041","authenticated-orcid":false,"given":"Md. 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