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The optimal target protein and the relevant molecular mechanisms for Sal B in the context of ALI were analysed using network pharmacology. Molecular dynamics simulations and BLI were performed on the core protein ALB\u2013compound Sal B identified through molecular docking. The pharmacological efficacy of Sal B and its underlying mechanisms were further substantiated through both in\u00a0vitro and in\u00a0vivo experiments, utilizing the LY294002 inhibitor and si\u2010ALB to confirm the involvement of ALB as a target. Additionally, RNA sequencing of murine lung tissues was conducted to further elucidate the molecular mechanism of Sal B. The results of network pharmacology indicated that a total of 155 potential target genes through which Sal B may exert its protective effects against ALI were identified, with essential pathways including PI3K\u2010AKT, TNF and IL\u201017 signalling pathways. Molecular docking, MD, and BLI demonstrated stable binding between Sal B and the core target ALB. In\u00a0vitro and in\u00a0vivo evidence confirmed that Sal B attenuates LPS\u2010induced ALI by inhibiting ferroptosis via the PI3K\/AKT axis, as corroborated by LY294002 and si\u2010ALB intervention. RNA sequencing and network pharmacological analysis synergistically revealed the PI3K\/AKT pathway as a potential signalling pathway for Sal B. Sal B ameliorates sepsis\u2010induced ALI via a defined mechanism that involves the activation of the PI3K\u2010AKT pathway, thereby inhibiting ferroptosis both in\u00a0vivo and in\u00a0vitro.<\/jats:p>","DOI":"10.1111\/jcmm.71344","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:49:16Z","timestamp":1788500956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvianolic Acid B Inhibits Ferroptosis in Acute Lung Injury: Network Analysis and Experimental Validation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-1639","authenticated-orcid":false,"given":"Hejun","family":"Gao","sequence":"first","affiliation":[{"name":"Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University Shanxi Provincial People's Hospital, The Fifth Clinical Medical College of Shanxi Medical University  Taiyuan China"},{"name":"Shanxi Key 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