{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:51Z","timestamp":1791996351699,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Periodontitis is an immune\u2010mediated inflammatory disease characterised by progressive alveolar bone loss, which can lead to tooth loss in severe cases. Existing therapeutic agents have limited efficacy in reversing the associated inflammatory bone defects. Exosomes (Exos), enriched with bioactive molecules, exhibit significant potential in anti\u2010inflammation and osteogenic regeneration. In this study, an injectable and photocurable composite hydrogel sustained\u2010release system (GA\u2010Exos) loaded with human umbilical cord blood\u2010derived exosomes (UCB\u2010Exos) was constructed. In\u00a0vitro and in\u00a0vivo experiments demonstrated that GA\u2010Exos possesses excellent performance, enabling sustained release of exosomes for approximately 21\u2009days. It significantly promotes the proliferation and differentiation of osteoblasts, upregulates the expression of osteogenic markers (e.g., RUNX2, ALP, and OPN), reduces the levels of pro\u2010inflammatory cytokines (e.g., TNF\u2010\u03b1 and IL\u20101\u03b2), and inhibits inflammatory cell infiltration and osteoclast differentiation. mRNA sequencing and validation experiments confirmed that UCB\u2010Exos inhibits the activation of the TLR4\/NF\u2010\u03baB pathway by downregulating the expression of TLR4, LBP, and CD14, as well as the phosphorylation of P65. In conclusion, GA\u2010Exos enhances periodontal bone regeneration through the regulation of the TLR4\/NF\u2010\u03baB pathway, providing a novel and effective strategy for periodontitis treatment. This system is expected to break through the limitations of existing therapies and bring new insights for clinical applications.<\/jats:p>","DOI":"10.1111\/jcmm.71347","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:49:55Z","timestamp":1790563795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Injectable Hydrogel Loaded With Umbilical Cord Blood\u2010Derived Exosomes Promotes Periodontal Bone Regeneration via the TLR4\/NF\u2010\u03baB Signalling Pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Dongao","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Stomatology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"College of Stomatology Bengbu Medical University  Bengbu Anhui 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