{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:54Z","timestamp":1789456074676,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Furong Tongmai capsule (FRTM) is a traditional Chinese medicine formula with reported lipid\u2010lowering and anti\u2010inflammatory activities, but its mechanisms in atherosclerosis (AS) remain unclear. In ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice fed a high\u2010fat diet, FRTM administration improved serum lipid profiles by reducing total cholesterol, triglycerides and low\u2010density lipoprotein cholesterol and increasing high\u2010density lipoprotein cholesterol. FRTM also attenuated aortic lesion formation, reduced pro\u2010inflammatory cytokines (IL\u20106, IL\u20101\u03b2 and TNF\u2010\u03b1), and improved oxidative stress indices. 16S rRNA sequencing showed that FRTM reshaped the gut microbiota, increasing beneficial taxa such as Lactobacillus and Bifidobacterium while decreasing Turicibacter. Functional prediction and untargeted serum metabolomics both suggested that arachidonic acid metabolism was a key pathway affected by FRTM. Furthermore, FRTM was associated with increased p\u2010PPAR\u03b3 and EP4 expression, decreased p\u2010P65, and increased p\u2010STAT3\/STAT3, accompanied by downregulation of M1 markers (iNOS\/Nos2) and upregulation of M2 markers (CD206 and ARG1). Faecal microbiota transplantation from FRTM\u2010treated donors partially recapitulated the anti\u2010atherosclerotic and anti\u2010inflammatory effects. Overall, these findings suggest that FRTM may ameliorate AS in a murine model by modulating gut microbiota, arachidonic acid metabolism and macrophage polarization; however, further functional studies are needed to establish causality and assess translational relevance.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71354","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:10:00Z","timestamp":1788844200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Furong Tongmai Capsule Ameliorates Atherosclerosis in\n                    <scp>ApoE<\/scp>\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice by Modulating Gut Microbiota, Arachidonic Acid Metabolism and Macrophage 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