{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:15Z","timestamp":1789456035574,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Apoptosis and functional loss of articular chondrocytes serve as initiating events in temporomandibular joint osteoarthritis (TMJOA), and FoxO3 represents a critical molecule for sustaining chondrocyte homeostasis. This study investigates the regulatory mechanism of the lncRNA\u2010OIP5\u2010AS1\/hsa\u2010miRNA\u2010223\u20103p\/FoxO3 axis in TMJOA, aiming to identify potential therapeutic targets for this disease. Single\u2010cell database analysis first revealed markedly reduced FoxO3 expression in TMJOA\u2010derived chondrocytes. A rat TMJOA model was then constructed and assigned to control, model, and FoxO3 overexpression groups; micro\u2010CT and histological staining, including HE and Safranin O\u2010fast green staining, were applied to assess articular cartilage injury, while immunohistochemistry was used to detect cartilage\u2010associated proteins Col2a1, MMP\u201013, Aggrecan, and ADAMTS\u20105. Further in\u00a0vitro experiments validated the chondroprotective function of FoxO3 as well as the binding interaction between FoxO3 and rno\u2010miRNA\u2010223\u20103p. Database screening confirmed significant down\u2010regulation of FoxO3 in TMJOA cartilage. Animal experiments demonstrated that FoxO3 overexpression mitigated chondrocyte injury in rat TMJOA lesions, increased Col2a1 and Aggrecan levels, and suppressed MMP\u201013 and ADAMTS\u20105 expression. Cellular assays showed that FoxO3 overexpression enhanced chondrocyte proliferation and matrix synthesis and preserved chondrocyte function. Sequencing and cellular evidence indicated that rno\u2010miRNA\u2010223\u20103p directly targets FoxO3 mRNA to repress its transcription and negatively modulate FoxO3 abundance, consequently aggravating chondrocyte apoptosis. Collectively, rno\u2010miRNA\u2010223\u20103p suppresses FoxO3 activity to facilitate TMJOA pathogenesis, and the lncRNA\u2010OIP5\u2010AS1\/rno\u2010miRNA\u2010223\u20103p\/FoxO3 regulatory cascade may act as a promising molecular target for TMJOA clinical intervention.<\/jats:p>","DOI":"10.1111\/jcmm.71359","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:31:31Z","timestamp":1789133491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>OIP5<\/scp>\n                    \u2010\n                    <scp>AS1<\/scp>\n                    Sponges\n                    <scp>miR<\/scp>\n                    \u2010223\u20103p to Upregulate\n                    <scp>FoxO3<\/scp>\n                    and Ameliorate Temporomandibular Joint Osteoarthritis by Inhibiting Chondrocyte Apoptosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0705-8894","authenticated-orcid":false,"given":"Xuesong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Stomatology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-2303","authenticated-orcid":false,"given":"Shichong","family":"Qiao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai China"},{"name":"Department of Implant Dentistry, College of Stomatology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14144921"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2022.48.1.50"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123283"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005390\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0746"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101665"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18271"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.02.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010024\u201000614\u20105"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000885\u2010y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70703"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659\u2010020\u201000309\u2010z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2023.151998"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.706"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/med\u20102023\u20100721"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519900801"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3385"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2025.2529033"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201910_19298"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176139"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13581"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2007697"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010025\u201002083\u20100"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201059883\u2010z"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010019\u20100047\u2010x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2015.40"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:19:31Z","timestamp":1789453171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jcmm.71359"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71359","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71359"}}