{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:08:28Z","timestamp":1790863708418,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a chronic inflammatory skin disorder driven by immune dysregulation and keratinocyte hyperproliferation. Calcitriol, the active form of vitamin D, shows therapeutic potential, but its molecular mechanisms remain incompletely understood.\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    (chitinase\u20103\u2010like protein 2) is a member of the chitinase\u2010like protein family implicated in inflammatory and tissue\u2010remodelling processes, yet its role in psoriasis has not been explored. Here, we investigated whether\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    mediates the anti\u2010psoriatic effects of calcitriol. Topical application of calcitriol alleviated imiquimod (IMQ)\u2010induced psoriasiform lesions in both unilateral and bilateral mouse ear models, as evidenced by reduced clinical scores, epidermal thickening and pro\u2010inflammatory cytokine expression (IL\u20101\u03b1, IL\u20106, IL\u201017A, IL\u201023A). In M5\u2010stimulated HaCaT cells, calcitriol reversed aberrant proliferation, migration and inflammatory responses, and restored keratin expression (KRT1\/KRT6). RNA\u2010seq identified\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    as the most significantly downregulated gene following calcitriol treatment.\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    knockdown phenocopied the protective effects of calcitriol, suppressing cell proliferation, migration and inflammation. Mechanistically, calcitriol downregulated\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    via inhibition of STAT3 phosphorylation at Tyr705. Collectively, these findings demonstrate that calcitriol ameliorates psoriatic inflammation and keratinocyte hyperproliferation through\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    downregulation mediated by the STAT3 pathway, highlighting\n                    <jats:italic>CHI3L2<\/jats:italic>\n                    as a potential therapeutic target for psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71367","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:01:11Z","timestamp":1789570871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Downregulating\n                    <scp>\n                      <i>CHI3L2<\/i>\n                    <\/scp>\n                    via the\n                    <scp>STAT3<\/scp>\n                    Pathway: The Mechanism of Calcitriol in Suppressing Psoriatic Inflammation and Keratinocyte Hyperproliferation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-7165","authenticated-orcid":false,"given":"Qingqing","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-122X","authenticated-orcid":false,"given":"Junlin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32549\u20106"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475420902047"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"97","article-title":"Current Developments in the Immunology of Psoriasis","volume":"93","author":"Gr\u00e4n F.","year":"2020","journal-title":"Yale Journal of Biology and 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