{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:30Z","timestamp":1792158630214,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["MQ2024026"],"award-info":[{"award-number":["MQ2024026"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Ym2023037"],"award-info":[{"award-number":["Ym2023037"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renal fibrosis, a defining feature of chronic kidney disease, involves a metabolic shift toward aerobic glycolysis and is frequently accompanied by ferroptosis, a form of iron\u2010dependent cell death. This study investigated the therapeutic potential of adipose mesenchymal stem cell\u2010derived exosomes (AMSC\u2010exo) in renal fibrosis. Using a unilateral ureteral obstruction (UUO) mouse model and hypoxia\u2010treated HK\u20102 cells, we assessed fibrosis, glycolysis, mitochondrial morphology, and ferroptosis. miRNA sequencing, dual\u2010luciferase reporter assays, and transcriptome sequencing were performed to identify key exosomal miRNAs and downstream pathways. AMSC\u2010exo significantly attenuated UUO\u2010induced fibrosis and suppressed glycolysis and ferroptosis in tubular epithelial cells. miR\u201026a\u20105p was highly enriched in AMSC\u2010exo and downregulated 6\u2010phosphofructo\u20102\u2010kinase\/fructose\u20102,6\u2010bisphosphatase 3 (Pfkfb3), a key regulator of glycolysis and ferroptosis. Knockdown of miR\u201026a\u20105p markedly weakened the renoprotective effects of AMSC\u2010exo, whereas Pfkfb3 inhibition reversed the effects induced by miR\u201026a\u20105p deficiency. These findings indicate that AMSC\u2010exo alleviate renal fibrosis by delivering miR\u201026a\u20105p to suppress Pfkfb3, thereby inhibiting glycolytic reprogramming and ferroptosis, and suggest the miR\u201026a\u20105p\/Pfkfb3 axis as a potential therapeutic target for renal fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.71369","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:06:43Z","timestamp":1792156003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adipose Mesenchymal Stem Cells Secreted Exosomal\n                    <scp>miR<\/scp>\n                    \u201026a\u20105p Ameliorate Renal Fibrosis via Inhibiting Glycolysis and Ferroptosis in Renal Interstitial Fibrosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-4182","authenticated-orcid":false,"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhuai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Affiliated Suqian Hospital of Xuzhou Medical University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8888-6389","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Medical School, Suzhou Hospital Nanjing University  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mam.2018.06.002","article-title":"Cellular and Molecular Mechanisms of Kidney Fibrosis","volume":"65","author":"Djudjaj S.","year":"2019","journal-title":"Molecular Aspects of 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D.","year":"2022","journal-title":"Kidney International"},{"issue":"9","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41419-023-06169-1","article-title":"SIRT2 Alleviated Renal Fibrosis by Deacetylating SMAD2 and SMAD3 in Renal Tubular Epithelial Cells","volume":"14","author":"Yang S.","year":"2023","journal-title":"Cell Death & Disease"},{"issue":"8","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","article-title":"Immunoregulatory Mechanisms of Mesenchymal Stem and Stromal Cells in Inflammatory Diseases","volume":"14","author":"Shi Y.","year":"2018","journal-title":"Nature Reviews Nephrology"},{"issue":"2","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/HYPERTENSIONAHA.121.14596","article-title":"Mesenchymal Stem\/Stromal Cell\u2010Derived Extracellular Vesicles for Chronic Kidney Disease: Are we There Yet?","volume":"78","author":"Eirin 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