{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:06:21Z","timestamp":1790863581100,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160433"],"award-info":[{"award-number":["82160433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20285"],"award-info":[{"award-number":["U22A20285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cartilage fibrosis contributes to extracellular matrix remodelling and structural deterioration during osteoarthritis (OA) progression; however, the molecular regulators involved in this process remain incompletely understood. Stanniocalcin\u20101 (STC1) has been implicated in tissue remodelling and fibrosis\u2010associated signalling, but its role in chondrocyte fibrotic phenotype transition remains unclear. In this study, primary mouse chondrocytes stimulated with interleukin\u20101\u03b2 (IL\u20101\u03b2), a destabilization of the medial meniscus (DMM) mouse model, and human OA cartilage samples were used to investigate the involvement of STC1 in OA\u2010associated fibrotic remodelling. Quantitative proteomic profiling identified STC1 as a differentially regulated candidate associated with inflammatory and fibrotic responses. STC1 expression was elevated under OA\u2010related conditions and was accompanied by increased SMAD2\/3 phosphorylation. In SW1353 chondrosarcoma\u2010derived chondrocytic cells, STC1 overexpression enhanced fibrosis\u2010associated phenotypic changes, including increased COL1A1, ADAMTS5, and MMP\u20103 expression, reduced COL2A1 expression, and increased SMAD2\/3 phosphorylation. Pharmacological modulation experiments further supported an association between STC1 and TGF\u2010\u03b2\/SMAD2\/3 signalling activity. Artemotil attenuated fibrotic and catabolic responses in IL\u20101\u03b2\u2010stimulated chondrocytes, reduced cartilage degeneration in DMM\u2010induced OA, and was associated with reduced STC1 expression and reduced SMAD2\/3 phosphorylation. Restoration of STC1 expression partially attenuated the effects of Artemotil on fibrosis\u2010related markers and signalling alterations. These findings support a functional association between STC1, TGF\u2010\u03b2\u2010responsive SMAD2\/3 signalling, and fibrosis\u2010associated chondrocyte remodelling in OA and identify this signalling relationship as responsive to Artemotil intervention.<\/jats:p>","DOI":"10.1111\/jcmm.71374","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:59:36Z","timestamp":1789570776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artemotil Attenuates Fibrosis\u2010Associated Chondrocyte Remodelling in Osteoarthritis in Association With\n                    <scp>STC1<\/scp>\n                    \u2010Related\n                    <scp>TGF<\/scp>\n                    \u2010\u03b2\/\n                    <scp>SMAD2<\/scp>\n                    \/3 Signalling"],"prefix":"10.1111","volume":"30","author":[{"given":"Guang","family":"Zhu","sequence":"first","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ma","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuanmin","family":"Tian","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"He","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4419-3847","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8806-6243","authenticated-orcid":false,"given":"Penggang","family":"Ma","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqun","family":"Tang","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"},{"name":"The First Clinical Medical College Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1249-4879","authenticated-orcid":false,"given":"Qunhua","family":"Jin","sequence":"additional","affiliation":[{"name":"The Third Ward of Orthopaedic Department, Institute of Osteoarthropathy, Institute of Medical Sciences General Hospital of Ningxia Medical University  Yinchuan Ningxia Hui Autonomous Region People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-01249"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1903768"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.12.006"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.03.015"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1780"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.11.005"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.10.016"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00624-0"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202512002"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2026.101127"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201601967"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.09.001"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104829"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.70091"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.12.007"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120717"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1717045"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000042281"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156498"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0445OC"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01545-x"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304123"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05351-4"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28257"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107802"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2022.5163"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8997-3_15"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.377"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190023"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(03)00156-0"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51746-3"},{"issue":"1","key":"e_1_2_14_34_1","article-title":"The Role of Fibrosis in Osteoarthritis Progression","volume":"11","author":"Rim Y. A.","year":"2020","journal-title":"Life (Basel)"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-026-06174-5"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-026-01662-x"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14727"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38315"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2026.1775478"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.02.005"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3251-z"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.08.004"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803991"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-022-01074-6"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-023-00918-9"},{"issue":"5","key":"e_1_2_14_46_1","article-title":"Induction of High Temperature Requirement A1, a Serine Protease, by TGF\u2010beta1 in Articular Chondrocytes of Mouse Models of OA","volume":"29","author":"Xu L.","year":"2014","journal-title":"Histology and Histopathology"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1377-8"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.166688"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158124"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.05.016"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.03.006"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42530"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abf3535"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2024.06.001"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:46:54Z","timestamp":1790862414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":53,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jcmm.71374"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71374","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71374"}}