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The gold standard for restoring the transected nerves is bridging the distal and proximal ends of disrupted autologous nerve using neurosurgical sutures. This approach is helpful, however nerve bridging is valid in pay of consuming healthy nerves and scarring phenomena in damaged site besides difficult donor nerve accessibility and extra surgery is required. Many studies have demonstrated that bFGF plays a pivotal role in the regeneration of PNI and severe spinal cord injury, exerting neuroprotective activity by binding to fibroblast growth factor receptors (FGFRs). Particularly, bFGF exhibits a high affinity for the receptor FGFR1, serving as its specific ligand. The novel synthetic compound SUN11602 exhibited neuroprotective activities like bFGF. Therefore, this study aimed to evaluate the effect of SUN11602 treatment in a rat experimental model of peripheral median nerve transection (MNT) and end\u2010to\u2010end suture. MNT was performed on rats, starting from 24\u2009h following the surgical procedure, to orally treat, daily for 7\u2009days, with SUN11602 at the dose of 2.5\u2009mg\/kg. The results showed that SUN11602 administration significantly reduced the alteration of PNI, promoting median nerve regeneration, suppressed mast cell accumulation, and resident macrophages. Also, SUN11602 reduced pro\u2010inflammatory response of M1 macrophages, stimulated Schwann cell proliferation, and slowed down median nerve demyelination and fibrosis. Therefore, SUN11602 could be considered a valuable pharmacological strategy for MNT.<\/jats:p>","DOI":"10.1111\/jcmm.71375","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:03:12Z","timestamp":1790409792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SUN<\/scp>\n                    11602 Accelerates Early Peripheral Nerve Regeneration in an Experimental Median Nerve Transection Model"],"prefix":"10.1111","volume":"30","author":[{"given":"Giovanna","family":"Casili","sequence":"first","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Papalia","sequence":"additional","affiliation":[{"name":"Department of Biological and Morphological Sciences and Imaging University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Ardizzone","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6411-5806","authenticated-orcid":false,"given":"Rossella","family":"Basilotta","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-4278","authenticated-orcid":false,"given":"Alfio Luca","family":"Costa","sequence":"additional","affiliation":[{"name":"Clinic of Plastic Surgery, Department of Neurosciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Titolo","sequence":"additional","affiliation":[{"name":"Reconstructive Microsurgery Unit, Department of Orthopedics &amp; Traumatology, AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-6387","authenticated-orcid":false,"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5586-4066","authenticated-orcid":false,"given":"Michele Rosario","family":"Colonna","sequence":"additional","affiliation":[{"name":"Department of Biological and Morphological Sciences and Imaging University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Galeano","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adult and Childhood \u201cG. 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