{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:06:08Z","timestamp":1790863568517,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571974"],"award-info":[{"award-number":["82571974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary cells continuously experience mechanical forces, yet the rapid expansion of mechanotransduction research has fragmented the knowledge base and obscured how research priorities have shifted over time. We therefore mapped the intellectual structure and thematic evolution of pulmonary mechanoregulation using bibliometric analysis and latent Dirichlet allocation (LDA). A total of 1896 articles and reviews published during 2000\u20132025 were retrieved from the Web of Science Core Collection and analysed with CiteSpace and LDA. Annual output increased from fewer than 60 publications per year before 2012 to more than 160 in 2024. Citation, co\u2010occurrence, clustering and burst analyses showed a transition from macroscopic injury paradigms, including cyclic stretch and alveolar overdistension, towards matrix stiffness. Yes\u2010associated protein\/transcriptional coactivator with PDZ\u2010binding motif (YAP\/TAZ) signalling, mechanosensitive ion channels and mechano\u2010immunology. LDA resolved 15 latent topics; idiopathic pulmonary fibrosis and macrophage activation was the largest topic (254 documents), while temporal modelling showed increasing prominence of macrophage\u2010centred fibrosis and viral\u2010associated lung injury and declining emphasis on classical mechanical stretch. These findings define major knowledge gaps at the biomechanics\u2013immunology interface and provide a quantitative roadmap for prioritizing biomimetic models, multi\u2010omics integration and selective mechanotherapeutic strategies.<\/jats:p>","DOI":"10.1111\/jcmm.71377","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:01:42Z","timestamp":1790388102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Mechanical Cues to Lung Injury: Mapping the Global Landscape and Frontiers of Mechanoregulation Through Bibliometrics and\n                    <scp>LDA<\/scp>\n                    Analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Liyan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"},{"name":"Department of Neonatology Dali Bai Autonomous Prefecture Maternal and Child Health Care Hospital  Dali China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-5518","authenticated-orcid":false,"given":"Yu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-2798","authenticated-orcid":false,"given":"Meiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-3536","authenticated-orcid":false,"given":"Sile","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Affiliated Hospital of Inner Mongolia Medical University  Huhehaote China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Xiangyang No. 1 People's Hospital, Hubei University of Medicine  Xiangyang 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