{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:46:40Z","timestamp":1791996400232,"version":"4.4.0"},"reference-count":125,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Major depression and anxiety disorders are psychiatric disorders that involve a great number of people. There is a growing need for new and better pharmacological treatments for these diseases. Kappa\u2010opioid receptor (KOR) antagonists seem to be a promising new pathway for the development of new antidepressants and anxiolytics, but a great challenge is understanding how the various neural circuits work and to what degree they are influenced by KOR modulators. This narrative review is focussed on two main circuits: the Hippocampus\u2010Amygdala\u2010Prefrontal Cortex and the Ventral Tegmental Area\u2010Nucleus Accumbens. The relevant neuroanatomy, their role in modulating behaviour and how KOR modulators can alleviate these diseases are discussed. Concluding, a more holistic understanding of the circuits influenced by the KOR\/Dyn system is relevant for developing new therapies. In non\u2010clinical pharmacology addressed to the KOR\/Dyn system, variables such as age, sex and social hierarchy rank can influence experimental outcomes.<\/jats:p>","DOI":"10.1111\/jcmm.71392","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:51:16Z","timestamp":1791348676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Kappa\u2010Opioid Receptor\/Dynorphin System in Modulating Neural\u2010Circuits of Depression and Anxiety\u2014A Review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3825-7621","authenticated-orcid":false,"given":"Cristian","family":"Ciotei","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-1974","authenticated-orcid":false,"given":"Horia","family":"P\u0103unescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6427-358X","authenticated-orcid":false,"given":"Cristina","family":"Lungu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9456-9530","authenticated-orcid":false,"given":"Adriana\u2010Alexandra","family":"Marica","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8264-6696","authenticated-orcid":false,"given":"Mihai Florin","family":"T\u0103nase","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra\u2010Cristina","family":"Marin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-7584","authenticated-orcid":false,"given":"Mihnea","family":"Costescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Fulga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Andreia","family":"Coman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology, Clinical Pharmacology and Pharmacotherapy Discipline \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-021-01019-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(23)00220-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001810"},{"key":"e_1_2_11_6_1","first-page":"5108","article-title":"Antidepressant Effect of the Interaction of Fluoxetine With Granisetron","volume":"18","author":"Costescu M.","year":"2019","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3195-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00253"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00170"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-024-01862-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0806-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046433"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0885-17.2017"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-023-02185-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90151-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.58"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114785"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.07.018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.5.2356"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.211623"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2003.09.028"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033814"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003181117"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0315-18.2018"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.03.006"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10279"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1331864"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.12.024"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15698"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3137-14.2015"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.184"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.306106"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00285-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.04.018"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1401.024"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.10.049"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90424-7"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780190065324.001.0001"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.05.002"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202413693"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.36255\/exonpublications.cerebralischemia.2021.hippocampus"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.031"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.56"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.011"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.04.009"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0842-6"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12604"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.005"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14188"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0370-20.2020"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.11.006"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09820"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0238-23.2023"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03593-1"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2022.963691"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000930"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4151-3"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-019-03007-9"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06809-7"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12490"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.05.002"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073875"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24931"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381"},{"key":"e_1_2_11_65_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM\u20105","year":"2013"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2023.03.004"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.09.007"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.013"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-9256-1-17"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.12.010"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.03.015"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.76"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.138"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02226-5"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0616-1"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.06.008"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1037\/emo0001130"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1177\/1754073915575402"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2022.111581"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2022.100493"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01168-2"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.02.066"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.12.007"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.074"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036743"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00432-6"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02589.x"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.045"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbii.2023.100017"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33401"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00175"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.03.017"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.18413\/rrpharmacology.10.400"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.005"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.016"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.894886"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.08.09.669424"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008528"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.083"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108456"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.01.002"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00677-6"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.01.001"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000897"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70395"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23785"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10883.2002"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107536"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.05.053"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.1052702"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00074"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.183905"},{"key":"e_1_2_11_113_1","first-page":"205","article-title":"PET Imaging Reveals Sex Differences in Kappa Opioid Receptor Availability in Humans, In\u00a0Vivo","volume":"6","author":"Vijay A.","year":"2016","journal-title":"American Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1901-11.2011"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108254"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2012-193"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24704"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.12.002"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3095-8"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00230.x"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.036"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01444-9"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00924"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0379-7"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0398-4"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0199-1"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.71392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.71392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:00:23Z","timestamp":1791993623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.71392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":125,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jcmm.71392"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.71392","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71392"}}