{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:53:10Z","timestamp":1791975190130,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2026ZD01910103"],"award-info":[{"award-number":["2026ZD01910103"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The coupled evolution of inflammation and metabolic dysfunction during early sepsis is incompletely characterized. Although C\u2010reactive protein (CRP) and albumin (ALB) are established markers of these processes, their joint longitudinal patterns have rarely been examined. We used group\u2010based dual\u2010trajectory modelling (GBDTM) to identify distinct coevolutionary patterns of CRP and ALB and to evaluate their associations with mortality in patients with sepsis. This retrospective observational study included patients admitted to the ICU of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, between June 2014 and March 2025. All included adults met the Sepsis\u20103 criteria. Among 462 patients with sepsis, serial CRP and ALB measurements obtained on days 1, 3, 5, 7 and 14 after ICU admission were analysed using GBDTM. The selected three\u2010class model showed acceptable classification quality (entropy\u2009=\u20090.80; class\u2010specific average posterior probabilities [AvePPs]\u2009=\u20090.84\u20130.92) and identified slow\u2010decreasing (79.65%), rapid\u2010decreasing (10.39%) and increasing (9.96%) inflammatory phenotypes. The 28\u2010day mortality rate was highest in the increasing group (52.2% vs. 32.6% and 33.3%; log\u2010rank\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034). In the fully adjusted Cox model, the increasing trajectory was associated with 28\u2010day mortality (HR 1.943, 95% CI: 1.202\u20133.140;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and 60\u2010day mortality (HR 1.946, 95% CI: 1.218\u20133.108;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). Parsimonious models adjusted for age, sex, and SOFA or the Acute Physiology and Chronic Health Evaluation II (APACHE II) score yielded broadly similar estimates. Joint CRP\u2010ALB trajectories identify clinically interpretable dynamic phenotypes during early sepsis. These findings support the joint trajectory as a hypothesis\u2010generating, complementary phenotyping marker that requires external prospective validation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.71402","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:32:51Z","timestamp":1791973971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Co\u2010Evolution of C\u2010Reactive Protein and Albumin in Early Sepsis: A Group\u2010Based Dual\u2010Trajectory Analysis for Risk Stratification"],"prefix":"10.1111","volume":"30","author":[{"given":"Tengfei","family":"Chen","sequence":"first","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases (BZ\u20102024\u2010078)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases (BZ\u20102024\u2010078)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4194-9298","authenticated-orcid":false,"given":"Maoyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases (BZ\u20102024\u2010078)  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-0906","authenticated-orcid":false,"given":"Xiaolong","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases (BZ\u20102024\u2010078)  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-0361","authenticated-orcid":false,"given":"Qingquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Traditional Chinese Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Research on Removing Stasis and Detoxification Theory in Infectious Diseases (BZ\u20102024\u2010078)  Beijing 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Albumin Levels as a Predictor of Mortality in Patients With Sepsis: A Multicenter Study","volume":"24","author":"Frenkel A.","year":"2022","journal-title":"Israel Medical Association Journal"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S414611"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202209_29662"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15081026"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911\u2010024\u201002629\u20106"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.01.004"},{"key":"e_1_2_14_18_1","doi-asserted-by":"crossref","DOI":"10.4159\/9780674041318","volume-title":"Group\u2010Based Modeling of Development","author":"Nagin D. 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