{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:59:51Z","timestamp":1777316391502,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T00:00:00Z","timestamp":1346198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIDCR","award":["R01DE019456"],"award-info":[{"award-number":["R01DE019456"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of localized aggressive periodontitis (<jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>) may include systemic antibiotics, yet it is unclear at what stage of treatment planning antibiotics are most effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective analysis compared immediate <jats:italic>versus<\/jats:italic> delayed antibiotic therapy on clinical parameters and gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) inflammatory mediators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>At baseline, 3 months and 6 months after treatment, clinical parameters [probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), bleeding on probing (<jats:styled-content style=\"fixed-case\">BoP<\/jats:styled-content>) and plaque] and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> were collected from <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> participants, who received a 7\u2010day antibiotic regimen immediately (<jats:styled-content style=\"fixed-case\">ImA<\/jats:styled-content>) or 3 months following (<jats:styled-content style=\"fixed-case\">DelA<\/jats:styled-content>) mechanical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although both groups presented significant <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> reductions at 6 months, only <jats:styled-content style=\"fixed-case\">ImA<\/jats:styled-content> resulted in a reduction in mean <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> at both 3 and 6 months, along with reductions in <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BoP<\/jats:styled-content> at 3 months following therapy. In addition, <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> mediators were higher in <jats:styled-content style=\"fixed-case\">DelA<\/jats:styled-content> group at 3 months post mechanical treatment, but were significantly reduced 6 months following antibiotic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ImA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DelA<\/jats:styled-content> regimens were both effective in improving <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> by 6 months post therapy. However, <jats:styled-content style=\"fixed-case\">ImA<\/jats:styled-content> allowed for better improvement in overall clinical parameters early in the course of treatment, concomitant with lower levels of inflammatory mediators within the <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12001","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T17:58:50Z","timestamp":1344016730000},"page":"1075-1081","source":"Crossref","is-referenced-by-count":20,"title":["Benefits of early systemic antibiotics in localized aggressive periodontitis: a retrospective study"],"prefix":"10.1111","volume":"39","author":[{"given":"Dennis","family":"Beliveau","sequence":"first","affiliation":[{"name":"University of Florida Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingvar","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Oral Biology University of Florida College of Dentistry Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Bidwell","sequence":"additional","affiliation":[{"name":"Leon County Health Department Tallahassee FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F.","family":"Zapert","sequence":"additional","affiliation":[{"name":"Leon County Health Department Tallahassee FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikramuddin","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon M.","family":"Wallet","sequence":"additional","affiliation":[{"name":"Department of Oral Biology University of Florida College of Dentistry Gainesville FL"},{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana M.","family":"Shaddox","sequence":"additional","affiliation":[{"name":"Department of Oral Biology University of Florida College of Dentistry Gainesville FL"},{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01795.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.9.723"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.675"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01717.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb01382.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.443"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01632.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00814.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00916.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.115"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00191.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01147.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01260.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.12.783"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060437"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01817.x"},{"key":"e_1_2_6_21_1","first-page":"811","article-title":"The use of 2 antibiotic regimens in aggressive periodontitis: comparison of changes in clinical parameters and gingival crevicular fluid biomarkers","volume":"39","author":"Machtei E. 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