{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T01:41:32Z","timestamp":1776649292924,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study set out to explore the possibility that chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) may also be a condition that could potentially result in secondary or symptomatic trigeminal neuralgia (<jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>) by utilizing a population\u2010based dataset and cohort study design in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We included 110,104 subjects with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> in our study cohort, and randomly selected 110,104 subjects without a history of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> as a comparison cohort. We individually tracked each patient in this study for a 5\u2010year period to identify those who received a subsequent diagnosis of <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> during the 5\u2010year follow\u2010up period was 4.40 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a03.87\u20134.98) per 10,000 person\u2010years for subjects with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, and 2.60 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a02.20\u20103.05) per 10,000 person\u2010years in comparison subjects. Cox proportional analysis revealed that the adjusted hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> during the 5\u2010year follow\u2010up period for subjects with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was 1.65 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.34\u20132.03) times higher than that of comparison subjects. However, the study subjects who had undergone a gingivectomy or periodontal flap operation did not have a higher adjusted risk of <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> than comparison subjects (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.93, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.54\u20131.61).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study detected a greater risk for <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> among patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> than matched comparison subjects<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12003","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T14:31:14Z","timestamp":1344954674000},"page":"1017-1023","source":"Crossref","is-referenced-by-count":7,"title":["Chronic periodontitis and the subsequent risk of trigeminal neuralgia: a 5\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"39","author":[{"given":"Joseph J.","family":"Keller","sequence":"first","affiliation":[{"name":"School of Public Health Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jau\u2010Jiuan","family":"Sheu","sequence":"additional","affiliation":[{"name":"Department of Neurology Taipei Medical University Taipei Taiwan"},{"name":"Neuroscience Research Center Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herng\u2010Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012290009545"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01916.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.3.297-a"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2089"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2087"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2298"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331979804900505"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6879.688"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2175"},{"key":"e_1_2_7_11_1","first-page":"568","article-title":"Mechanisms of arterial and aneurysmal tortuosity","volume":"104","author":"Dobrin P. 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