{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:09:59Z","timestamp":1790845799688,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:00:00Z","timestamp":1348704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To evaluate the effects of the adjunctive use of metronidazole (MTZ<\/jats:styled-content>) or MTZ<\/jats:styled-content>\u00a0+\u00a0amoxicillin (AMX<\/jats:styled-content>) in the treatment of generalized chronic periodontitis (ChP). A secondary aim was to examine a possible added effect of chlorhexidine to these therapies.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and eighteen subjects received scaling and root planing (SRP<\/jats:styled-content>) only or with MTZ<\/jats:styled-content> [400\u00a0mg\/thrice a day (TID<\/jats:styled-content>)] or MTZ<\/jats:styled-content>+AMX<\/jats:styled-content> (500\u00a0mg\/TID<\/jats:styled-content>) for 14\u00a0days. Half of the subjects in each group rinsed with 0.12% chlorhexidine twice a day (BID) for 2\u00a0months. Subjects were clinically monitored at baseline, 3, 6 and 12\u2010months post\u2010therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>The two antibiotic groups showed lower mean number of sites with probing depth (PD<\/jats:styled-content>) \u22655\u00a0mm and fewer subjects exhibiting \u22659 of these sites at 1\u2010year post\u2010treatment. Logistic regression analysis showed that antibiotics were the only significant predictors of subjects presenting \u22644 sites with PD<\/jats:styled-content> \u22655\u00a0mm at 1\u00a0year (MTZ<\/jats:styled-content>+AMX<\/jats:styled-content>: OR<\/jats:styled-content>, 13.33; 95%CI<\/jats:styled-content>, 3.75\u201047.39\/p<\/jats:italic>\u00a0=\u00a00.0000; MTZ<\/jats:styled-content>: OR<\/jats:styled-content>, 7.26; 95%CI<\/jats:styled-content>, 2.26\u201023.30\/p<\/jats:italic>\u00a0=\u00a00.0004). The frequency of adverse events did not differ between the two antibiotic treatments (p<\/jats:italic>\u00a0>\u00a00.05). The chlorhexidine subgroups showed a trend (p<\/jats:italic>\u00a0>\u00a00.05) to present fewer residual sites \u22655\u00a0mm compared with the placebo subgroups at 1\u00a0year.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Treatment of generalized ChP is significantly improved by the adjunctive use of MTZ<\/jats:styled-content>+AMX<\/jats:styled-content> and MTZ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12004","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T10:45:10Z","timestamp":1345113910000},"page":"1149-1158","source":"Crossref","is-referenced-by-count":129,"title":["Metronidazole alone or with amoxicillin as adjuncts to non\u2010surgical treatment of chronic periodontitis: a 1\u2010year double\u2010blinded, placebo\u2010controlled, randomized clinical trial"],"prefix":"10.1111","volume":"39","author":[{"given":"Magda","family":"Feres","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geisla Mary Silva","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Alethusa Velloso","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike Paulino","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Teles","sequence":"additional","affiliation":[{"name":"The Forsyth Institute Cambridge MA USA"},{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigmund S.","family":"Socransky","sequence":"additional","affiliation":[{"name":"The Forsyth Institute Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01795.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00605.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080540"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.5.749"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01471.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028007597.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01870.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0225"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00814.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.115"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2003.tb00770.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01040.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.8.x"},{"key":"e_1_2_6_16_1","first-page":"7","article-title":"Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT)","volume":"1","author":"Lang N. 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