{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:08:29Z","timestamp":1790694509551,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T00:00:00Z","timestamp":1348963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Universal strategies for managing peri\u2010implantitis are yet to be adopted. The aim of this study is to examine a protocol of intensive application of chlorhexidine containing chips in sites with peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This multi\u2010centre, randomized, double\u2010blind, parallel, two\u2010arm clinical trial included 60 patients (77 implants) with probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) 6\u201310\u00a0mm and bone loss \u22652\u00a0mm around 1\u20132 implants. One to two weeks following <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>, baseline measurements were made followed by implants' debridement. Patients were randomized to receive matrix chips (MatrixC) or chlorhexidine Chips (PerioC). Measurements and chips placement were repeated at weeks 2, 4, 6, 8, 12 and 18. At 6\u00a0months, patients returned for final examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Probing depth reduction was greater in the PerioC (2.19\u00a0\u00b1\u00a00.24\u00a0mm) compared with MatrixC (1.59\u00a0\u00b1\u00a00.23\u00a0mm), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.07. Seventy percentage of the implants in the PerioC and 54% in the MatrixC had <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction\u00a0\u2265\u00a02\u00a0mm. Likewise, 40% of the sites (PerioC) and 24% (MatrixC) had <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction\u00a0\u2265\u00a03\u00a0mm. Clinical attachment level gains for both groups were significant; however, the changes in the PerioC group were significantly greater than in MatrixC [2.21\u00a0\u00b1\u00a00.23\u00a0mm. and 1.56\u00a0\u00b1\u00a00.25\u00a0mm respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05]. Bleeding on probing was reduced by half in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Frequent placement of PerioC and MatrixC together with implants debridement resulted in a substantial improvement in sites with peri\u2010implantitis. Further studies will be required to fully appreciate the mechanism of this treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12006","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T05:15:09Z","timestamp":1345785309000},"page":"1198-1205","source":"Crossref","is-referenced-by-count":58,"title":["Treatment of peri\u2010implantitis using multiple applications of chlorhexidine chips: a double\u2010blind, randomized multi\u2010centre clinical trial"],"prefix":"10.1111","volume":"39","author":[{"given":"Eli E.","family":"Machtei","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam HCC and Faculty of Medicine Technion \u2013 Israeli Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Frankenthal","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam HCC and Faculty of Medicine Technion \u2013 Israeli Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam HCC and Faculty of Medicine Technion \u2013 Israeli Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Elimelech","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam HCC and Faculty of Medicine Technion \u2013 Israeli Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Shoshani","sequence":"additional","affiliation":[{"name":"Dexcel Pharma Or\u2010Akiva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirit","family":"Tagger\u2010Green","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Shlomi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32170"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.06.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02264.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2011.00384.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1980.tb01217.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02078.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291102.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.989"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01453.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090269"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050401"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01674.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01779.x"},{"key":"e_1_2_6_16_1","unstructured":"Markets for Dental Implants and Final Abutments 2009 iDada Research Inc. 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