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An enzyme\u2010linked immunosorbent assay (ELISA) kit was used to quantify <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 levels in collected crevicular fluid. Recorded clinical parameters were probing pocket depth (PPD), bleeding upon probing, tooth mobility, plaque index (PlI), and gingival index (GI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 level in collected fluid was significantly higher in pathological sites than in healthy sites from either periodontal or control patients: 353.9\u00a0pg\/ml, 50.2\u00a0pg\/ml and 25.4\u00a0pg\/ml respectively. Soluble TREM\u20101 concentration was significantly correlated with PPD. The <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 levels increased with the augmentation of the PlI and GI scores and levelled off at score 2 for both indexes. In multivariate analysis, periodontal pocket depth and smoking status were statistically associated with highest <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 was detected in crevicular fluid and its concentration was higher in pathological sites. It could be a marker of periodontal tissue destruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12008","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T07:11:05Z","timestamp":1345446665000},"page":"1141-1148","source":"Crossref","is-referenced-by-count":36,"title":["Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (<scp>sTREM<\/scp>) \u20101 in severe periodontitis"],"prefix":"10.1111","volume":"39","author":[{"given":"Catherine","family":"Bisson","sequence":"first","affiliation":[{"name":"D\u00e9partement de parodontologie Universit\u00e9 Henri Poincar\u00e9 Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Massin","sequence":"additional","affiliation":[{"name":"Laboratoire d'immunologie plate\u2010forme NANCYTOMIQUE H\u00f4pital de Brabois Vandoeuvre les Nancy 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