{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:22:35Z","timestamp":1772140955228,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the variations in salivary concentrations of <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>, osteoprotegerin (OPG) and its ratio, regarding the periodontal status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ninety\u2010seven chronic periodontitis (CP) subjects and 43 healthy controls were selected. Periodontal status was assessed based on full\u2010mouth clinical periodontal measurements. <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> and OPG salivary levels were analysed by ELISA. The association between these analytes and its ratio with CP was analysed individually and adjusted for confounding using a binary logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>\/OPG ratio were increased, whereas OPG was decreased in CP compared with healthy controls subjects. Although univariate analysis revealed a positive association of <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> salivary levels \u22656\u00a0pg\/ml, OPG salivary levels \u2264131\u00a0pg\/ml and <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>\/OPG ratio \u22650.062 with CP, after logistic regression analysis only the latter parameter was strongly and independently associated with disease status. Confounding and interaction effects of ageing and smoking habit on <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> and OPG levels could be noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although salivary concentrations of <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>, OPG and its ratio may act as indicators of the amount\/extent of periodontal breakdown, the mutual confounding and synergistic biological interactive effects related to ageing and smoking habit of the susceptible host may also promote the tissue destruction in CP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12012","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T18:25:40Z","timestamp":1346523940000},"page":"1132-1140","source":"Crossref","is-referenced-by-count":36,"title":["Association of salivary levels of the bone remodelling regulators <scp>sRANKL<\/scp> and OPG with periodontal clinical status"],"prefix":"10.1111","volume":"39","author":[{"given":"Sergio I.","family":"Tob\u00f3n\u2010Arroyave","sequence":"first","affiliation":[{"name":"POPCAD Research Group Laboratory of Immunodetection and Bioanalysis Faculty of Dentistry University of Antioquia Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Isaza\u2010Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"POPCAD Research Group Laboratory of Immunodetection and Bioanalysis Faculty of Dentistry University of Antioquia Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana M.","family":"Restrepo\u2010Cadavid","sequence":"additional","affiliation":[{"name":"POPCAD Research Group Laboratory of Immunodetection and Bioanalysis Faculty of Dentistry University of Antioquia Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra 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