{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:10:53Z","timestamp":1780596653453,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T00:00:00Z","timestamp":1349827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Geistlich Pharma AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical outcomes of the use of a xenogeneic collagen matrix (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) in combination with the coronally advanced flap (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>) in the treatment of localized recession defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material &amp; Methods<\/jats:title><jats:p>In a multicentre single\u2010blinded, randomized, controlled, split\u2010mouth trial, 90 recessions (Miller I, II) in 45 patients received either <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u00a0months, root coverage (primary outcome) was 75.29% for test and 72.66% for control defects (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.169), with 36% of test and 31% of control defects exhibiting complete coverage. The increase in mean width of keratinized tissue (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>) was higher in test (from 1.97 to 2.90\u00a0mm) than in control defects (from 2.00 to 2.57\u00a0mm) (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.036). Likewise, test sites had more gain in gingival thickness (<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>) (0.59\u00a0mm) than control sites (0.34\u00a0mm) (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.003). Larger (\u22653\u00a0mm) recessions (<jats:italic>n\u00a0<\/jats:italic>=\u00a035 patients) treated with <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> showed higher root coverage (72.03% <jats:italic>versus<\/jats:italic> 66.16%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.043), as well as more gain in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> was not superior with regard to root coverage, but enhanced gingival thickness and width of keratinized tissue when compared with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> alone. For the coverage of larger defects, <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> was more effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12019","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T15:31:54Z","timestamp":1347377514000},"page":"82-89","source":"Crossref","is-referenced-by-count":146,"title":["Treatment of gingival recession defects with a coronally advanced flap and a xenogeneic collagen matrix: a multicenter randomized clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Karin","family":"Jepsen","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Zucchelli","sequence":"additional","affiliation":[{"name":"Department of Stomatology Bologna University Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Stefanini","sequence":"additional","affiliation":[{"name":"Department of Stomatology Bologna University Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"Department of Periodontology Siena University Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Baldini","sequence":"additional","affiliation":[{"name":"Department of Periodontology Siena University Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Greven","sequence":"additional","affiliation":[{"name":"Private Practice Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Heinz","sequence":"additional","affiliation":[{"name":"Private Practice Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wennstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of G\u00f6teborg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Cassel","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of G\u00f6teborg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Vignoletti","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00225.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01903.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01267.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01839.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110215"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110382"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090540"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01346.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01039.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110023"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090698"},{"key":"e_1_2_6_13_1","first-page":"8","article-title":"A classification of marginal tissue recession","volume":"5","author":"Miller P. 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